MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension

Pulmonary hypertension (PH) results in pressure overload of the right ventricle (RV) of the heart, initiating pathological RV remodeling and ultimately leading to right heart failure. Substantial research indicates that signaling through the MAPK superfamily mediates pathological cardiac remodeling....

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2013-01, Vol.304 (2), p.H269-H281
Hauptverfasser:	Brown, R Dale, Ambler, S Kelly, Li, Min, Sullivan, Timothy M, Henry, Lauren N, Crossno, Jr, Joseph T, Long, Carlin S, Garrington, Timothy P, Stenmark, Kurt R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic Disease Disease Models, Animal Gene expression Gene Expression Regulation Heart failure Heart Ventricles - diagnostic imaging Heart Ventricles - enzymology Heart Ventricles - physiopathology Hypertension Hypertension, Pulmonary - diagnostic imaging Hypertension, Pulmonary - enzymology Hypertension, Pulmonary - etiology Hypertension, Pulmonary - genetics Hypertension, Pulmonary - physiopathology Hypertrophy, Right Ventricular - diagnostic imaging Hypertrophy, Right Ventricular - enzymology Hypertrophy, Right Ventricular - etiology Hypertrophy, Right Ventricular - genetics Hypertrophy, Right Ventricular - physiopathology Hypertrophy, Right Ventricular - prevention & control Hypoxia Hypoxia - complications Hypoxia - enzymology Hypoxia - genetics Inflammation Mediators - metabolism Kinases Male MAP Kinase Kinase Kinase 2 - deficiency MAP Kinase Kinase Kinase 2 - genetics MAP Kinase Kinase Kinase 2 - metabolism Mice Mice, Knockout Mitogen-Activated Protein Kinase 7 - metabolism Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Phosphorylation Rodents Signaling and Stress Response Time Factors Ultrasonography Ventricular Remodeling
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