Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle

Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo exist as part of complex 3D structures, and it is well established in other cell types that altering substrate geometry exerts potent effects o...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2013-01, Vol.304 (1), p.L4-L16
Hauptverfasser:	West, Adrian R, Zaman, Nishat, Cole, Darren J, Walker, Matthew J, Legant, Wesley R, Boudou, Thomas, Chen, Christopher S, Favreau, John T, Gaudette, Glenn R, Cowley, Elizabeth A, Maksym, Geoffrey N
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Animals Asthma Asthma - physiopathology Bioengineering Call for Papers Cell culture Coculture Techniques Fibers Gauges Gene Expression Humans Life Sciences Mice Models, Biological Molecular biology Muscle Contraction - physiology Muscle, Smooth - cytology NIH 3T3 Cells Respiratory System - cytology Smooth muscle Stress, Mechanical Substrates Tissue Culture Techniques - methods Tissue engineering Tissue Engineering - methods
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