The β Sliding Clamp Closes around DNA prior to Release by the Escherichia coli Clamp Loader γ Complex

Escherichia coli γ complex clamp loader functions to load the β sliding clamp onto sites of DNA replication and repair. The clamp loader uses the energy of ATP binding and hydrolysis to drive conformational changes allowing for β binding and opening, DNA binding, and then release of the β·DNA comple...

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Veröffentlicht in:	The Journal of biological chemistry 2013-01, Vol.288 (2), p.1162-1170
Hauptverfasser:	Hayner, Jaclyn N., Bloom, Linda B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism ATPases Clamp Loader DNA and Chromosomes DNA Enzymes DNA Replication DNA, Bacterial - metabolism Enzyme Kinetics Escherichia coli - genetics Escherichia coli Proteins - metabolism Hydrolysis Pre-steady-state Kinetics Protein-Protein Interactions Sliding Clamp
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