Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men

Suvorexant (MK-4305) is an orexin receptor antagonist being developed for the treatment of insomnia. This report describes the effects of nighttime administration of suvorexant on polysomnography (PSG) sleep parameters in healthy young men. Randomized, double-blind, placebo-controlled, 4-period cros...

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Veröffentlicht in:	Sleep (New York, N.Y.) N.Y.), 2013-02, Vol.36 (2), p.259-267
Hauptverfasser:	Sun, Hong, Kennedy, William P, Wilbraham, Darren, Lewis, Nicole, Calder, Nicole, Li, Xiaodong, Ma, Junshui, Yee, Ka Lai, Ermlich, Susan, Mangin, Eric, Lines, Christopher, Rosen, Laura, Chodakewitz, Jeffrey, Murphy, Gail M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Azepines - adverse effects Azepines - pharmacokinetics Azepines - pharmacology Cross-Over Studies Double-Blind Method Effects of an Orexin Receptor Antagonist on Sleep Humans Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - pharmacokinetics Hypnotics and Sedatives - pharmacology Male Orexin Receptors Polysomnography Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, Neuropeptide - antagonists & inhibitors Sleep - drug effects Sleep - physiology Triazoles - adverse effects Triazoles - pharmacokinetics Triazoles - pharmacology Young Adult
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