Specificity of the Double-Stranded RNA-Binding Domain from the RNA-Activated Protein Kinase PKR for Double-Stranded RNA: Insights from Thermodynamics and Small-Angle X‑ray Scattering

The interferon-inducible, double-stranded (ds) RNA-activated protein kinase (PKR) contains a dsRNA-binding domain (dsRBD) and plays key roles in viral pathogenesis and innate immunity. Activation of PKR is typically mediated by long dsRNA, and regulation of PKR is disfavored by most RNA imperfection...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2012-11, Vol.51 (46), p.9312-9322
Hauptverfasser:	Patel, Sunita, Blose, Joshua M, Sokoloski, Joshua E, Pollack, Lois, Bevilacqua, Philip C
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Calorimetry eIF-2 Kinase - metabolism Electrophoretic Mobility Shift Assay Molecular Sequence Data RNA, Double-Stranded - chemistry RNA, Double-Stranded - metabolism Scattering, Small Angle Thermodynamics X-Ray Diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!