Genomic Pathology of SLE-Associated Copy-Number Variation at the FCGR2C/FCGR3B/FCGR2B Locus

Reduced FCGR3B copy number is associated with increased risk of systemic lupus erythematosus (SLE). The five FCGR2/FCGR3 genes are arranged across two highly paralogous genomic segments on chromosome 1q23. Previous studies have suggested mechanisms for structural rearrangements at the FCGR2/FCGR3 lo...

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Veröffentlicht in:	American journal of human genetics 2013-01, Vol.92 (1), p.28-40
Hauptverfasser:	Mueller, Michael, Barros, Paula, Witherden, Abigail S., Roberts, Amy L., Zhang, Zhou, Schaschl, Helmut, Yu, Chack-Yung, Hurles, Matthew E., Schaffner, Catherine, Floto, R. Andres, Game, Laurence, Steinberg, Karyn Meltz, Wilson, Richard K., Graves, Tina A., Eichler, Evan E., Cook, H. Terence, Vyse, Timothy J., Aitman, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Mapping Chromosomes Cloning DNA Copy Number Variations Flow cytometry Gene Deletion Gene loci Genetic Predisposition to Disease Genomics GPI-Linked Proteins - genetics Humans Killer Cells, Natural - metabolism Lupus Erythematosus, Systemic - genetics Pathology Polymorphism, Single Nucleotide Receptors, IgG - genetics
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