Fingerloop activates cargo delivery and unloading during cotranslational protein targeting

During cotranslational protein targeting by the signal recognition particle (SRP), information about signal sequence binding in the SRP's M domain must be effectively communicated to its GTPase domain to turn on its interaction with the SRP receptor (SR) and thus deliver the cargo proteins to t...

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Veröffentlicht in:	Molecular biology of the cell 2013-01, Vol.24 (2), p.63-73
Hauptverfasser:	Ariosa, Aileen R, Duncan, Stacy S, Saraogi, Ishu, Lu, Xiaodong, Brown, April, Phillips, Gregory J, Shan, Shu-Ou
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Bacterial Proteins - metabolism Endoplasmic Reticulum - metabolism Enzyme Activation Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism GTP Phosphohydrolases - metabolism Kinetics Molecular Sequence Data Mutagenesis, Site-Directed Mutation Protein Binding Protein Modification, Translational Protein Sorting Signals Protein Transport Receptors, Cytoplasmic and Nuclear - metabolism RNA, Bacterial - metabolism Signal Recognition Particle - chemistry Signal Recognition Particle - genetics Signal Recognition Particle - metabolism
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