AGR2 Is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic can...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-11, Vol.71 (22), p.7091-7102
Hauptverfasser:	DUMARTIN, Laurent, WHITEMAN, Hannah J, BRENNAN, Caroline, LEMOINE, Nicholas R, CRNOGORAC-JURCEVIC, Tatjana, WEEKS, Mark E, HARIHARAN, Deepak, DMITROVIC, Branko, LACOBUZIO-DONAHUE, Christine A, BRENTNALL, Teresa A, BRONNER, Mary P, FEAKINS, Roger M, TIMMS, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - pathology Animals Antigens, Surface - physiology Antineoplastic agents Biological and medical sciences Carcinoma, Pancreatic Ductal - pathology Cathepsin B Cathepsin B - genetics Cathepsin B - physiology Cathepsin D Cathepsin D - genetics Cathepsin D - physiology Cell Line, Tumor Cell surface Chaperones Confocal microscopy Endoplasmic reticulum Endoplasmic Reticulum - metabolism Flow cytometry Gastroenterology. Liver. Pancreas. Abdomen Humans Invasiveness Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Metastases Mucoproteins Neoplasm Invasiveness Oncogene Proteins Pancreatic cancer Pancreatic Neoplasms - pathology Pharmacology. Drug treatments proteasomes Proteinase Proteins - physiology Proteome Secretion surface antigens Tumor cells Tumors Ubiquitin Zebrafish
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