Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium
Aims:Excessive lipid accumulation in Bruch’s membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity to move lipid into BrM, mediated through ATP-binding...
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| Veröffentlicht in: | British journal of ophthalmology 2009-08, Vol.93 (8), p.1116-1120 |
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| container_title | British journal of ophthalmology |
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| creator | Duncan, K G Hosseini, K Bailey, K R Yang, H Lowe, R J Matthes, M T Kane, J P LaVail, M M Schwartz, D M Duncan, J L |
| description | Aims:Excessive lipid accumulation in Bruch’s membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity to move lipid into BrM, mediated through ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI).Methods:ABCA1 expression was assessed by reverse transcription polymerase chain reaction (RT-PCR) and western blotting of human RPE cell extracts. Lipid transport assays were performed using radiolabelled photoreceptor outer segments (POS). ABCA1 and SR-BI expression was examined in normal mouse eyes by immunofluorescence staining. BrMs of ABCA1 and SR-BI heterozygous mice were examined microscopically.Results:Human RPE cells expressed ABCA1 mRNA and protein. The ABCA1 and SR-BI inhibitor glyburide (also known as glibenclamide) abolished basal transport of POS-derived lipids in RPE cells in the presence of high-density lipoprotein. Mouse retina and RPE expressed ABCA1 and SR-BI. SR-BI was highly expressed in RPE. BrMs were significantly thickened in SR-BI heterozygous mice, but not in ABCA1 heterozygous mice.Conclusion:RPE cells express ABCA1 and SR-BI. This implies a significant role for SR-BI and ABCA1 in lipid transport and RCT in the retina and RPE. |
| doi_str_mv | 10.1136/bjo.2008.144006 |
| format | Article |
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Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity to move lipid into BrM, mediated through ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI).Methods:ABCA1 expression was assessed by reverse transcription polymerase chain reaction (RT-PCR) and western blotting of human RPE cell extracts. Lipid transport assays were performed using radiolabelled photoreceptor outer segments (POS). ABCA1 and SR-BI expression was examined in normal mouse eyes by immunofluorescence staining. BrMs of ABCA1 and SR-BI heterozygous mice were examined microscopically.Results:Human RPE cells expressed ABCA1 mRNA and protein. The ABCA1 and SR-BI inhibitor glyburide (also known as glibenclamide) abolished basal transport of POS-derived lipids in RPE cells in the presence of high-density lipoprotein. Mouse retina and RPE expressed ABCA1 and SR-BI. SR-BI was highly expressed in RPE. BrMs were significantly thickened in SR-BI heterozygous mice, but not in ABCA1 heterozygous mice.Conclusion:RPE cells express ABCA1 and SR-BI. This implies a significant role for SR-BI and ABCA1 in lipid transport and RCT in the retina and RPE.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2008.144006</identifier><identifier>PMID: 19304587</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adult ; Animals ; ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters - genetics ; ATP-Binding Cassette Transporters - metabolism ; Biological and medical sciences ; Bruch Membrane - ultrastructure ; Cells, Cultured ; Electroretinography ; Eye Proteins - metabolism ; Gene Expression ; Humans ; Lipid Metabolism ; Lipids ; Macular degeneration ; Medical sciences ; Mice ; Mice, Mutant Strains ; Microscopy, Electron ; Miscellaneous ; Mutation ; Ophthalmology ; Retina - metabolism ; Retina - physiology ; Retinal Pigment Epithelium - metabolism ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - genetics ; Rodents ; Scavenger Receptors, Class B - metabolism</subject><ispartof>British journal of ophthalmology, 2009-08, Vol.93 (8), p.1116-1120</ispartof><rights>BMJ Publishing Group Ltd. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2009 BMJ Publishing Group Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b588t-4210b4f1e9e6857c18b5d1adb69ec151e5dd5d3874dafe99d50292b879313b913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/93/8/1116.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/93/8/1116.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,723,776,780,881,3183,23552,27903,27904,53769,53771,77346,77377</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21731250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19304587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duncan, K G</creatorcontrib><creatorcontrib>Hosseini, K</creatorcontrib><creatorcontrib>Bailey, K R</creatorcontrib><creatorcontrib>Yang, H</creatorcontrib><creatorcontrib>Lowe, R J</creatorcontrib><creatorcontrib>Matthes, M T</creatorcontrib><creatorcontrib>Kane, J P</creatorcontrib><creatorcontrib>LaVail, M M</creatorcontrib><creatorcontrib>Schwartz, D M</creatorcontrib><creatorcontrib>Duncan, J L</creatorcontrib><title>Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Aims:Excessive lipid accumulation in Bruch’s membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity to move lipid into BrM, mediated through ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI).Methods:ABCA1 expression was assessed by reverse transcription polymerase chain reaction (RT-PCR) and western blotting of human RPE cell extracts. Lipid transport assays were performed using radiolabelled photoreceptor outer segments (POS). ABCA1 and SR-BI expression was examined in normal mouse eyes by immunofluorescence staining. BrMs of ABCA1 and SR-BI heterozygous mice were examined microscopically.Results:Human RPE cells expressed ABCA1 mRNA and protein. The ABCA1 and SR-BI inhibitor glyburide (also known as glibenclamide) abolished basal transport of POS-derived lipids in RPE cells in the presence of high-density lipoprotein. Mouse retina and RPE expressed ABCA1 and SR-BI. SR-BI was highly expressed in RPE. BrMs were significantly thickened in SR-BI heterozygous mice, but not in ABCA1 heterozygous mice.Conclusion:RPE cells express ABCA1 and SR-BI. This implies a significant role for SR-BI and ABCA1 in lipid transport and RCT in the retina and RPE.</description><subject>Adult</subject><subject>Animals</subject><subject>ATP Binding Cassette Transporter 1</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>Biological and medical sciences</subject><subject>Bruch Membrane - ultrastructure</subject><subject>Cells, Cultured</subject><subject>Electroretinography</subject><subject>Eye Proteins - metabolism</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Macular degeneration</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Microscopy, Electron</subject><subject>Miscellaneous</subject><subject>Mutation</subject><subject>Ophthalmology</subject><subject>Retina - metabolism</subject><subject>Retina - physiology</subject><subject>Retinal Pigment Epithelium - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - genetics</subject><subject>Rodents</subject><subject>Scavenger Receptors, Class B - metabolism</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkl9v0zAUxSMEYmPwzBuyhEAbUjrfJI6dF6S22kZRNRArvFpOctu6JHaw02p8Hr4oLqnKnxeebOv8fHSuj6PoOdARQJpflhs7SigVI8gySvMH0SlkuYgTyouH0SmllMcAOZxET7zfhGOSA38cnUCR0owJfhr9uLrvHHqvrSF2SRzu0Hkk1do26Ht0tiG9U8Z31vWkc7ZHbTwZLz7GpTa1NitSKe-x75GMgZyPJ9MxXBBlauIrtUOzQhdMK-x668hkRs7vPsWT2QXRhvRrDFKvjfrFD9uGdHrVoukJdjoQjd62T6NHS9V4fHZYz6LP11eL6bt4_uFmNh3P45IJ0cdZArTMloAF5oLxCkTJalB1mRdYAQNkdc3qVPCsVkssiprRpEhKwYsU0rKA9Cx6O_h227LFugopnGpk53Sr3HdplZZ_K0av5cruZMoyoIkIBq8PBs5-24b3k632FTaNMmi3XuacQcFEEcCX_4Abu3Vhei-Bc7EPlPNAXQ5U5az3DpfHKEDlvn4Z6pf7-uVQf7jx4s8JfvOHvgPw6gCo0E-zDNVW2h-5BHgKCaOBiwdOh09wf9SV-xqGSDmTt1-m8ub9_G4xub6VWeDfDHzZbv6b8ieDB9Xi</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Duncan, K G</creator><creator>Hosseini, K</creator><creator>Bailey, K R</creator><creator>Yang, H</creator><creator>Lowe, R J</creator><creator>Matthes, M T</creator><creator>Kane, J P</creator><creator>LaVail, M M</creator><creator>Schwartz, D M</creator><creator>Duncan, J L</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090801</creationdate><title>Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium</title><author>Duncan, K G ; Hosseini, K ; Bailey, K R ; Yang, H ; Lowe, R J ; Matthes, M T ; Kane, J P ; LaVail, M M ; Schwartz, D M ; Duncan, J L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b588t-4210b4f1e9e6857c18b5d1adb69ec151e5dd5d3874dafe99d50292b879313b913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Animals</topic><topic>ATP Binding Cassette Transporter 1</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>Biological and medical sciences</topic><topic>Bruch Membrane - ultrastructure</topic><topic>Cells, Cultured</topic><topic>Electroretinography</topic><topic>Eye Proteins - metabolism</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Macular degeneration</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Microscopy, Electron</topic><topic>Miscellaneous</topic><topic>Mutation</topic><topic>Ophthalmology</topic><topic>Retina - metabolism</topic><topic>Retina - physiology</topic><topic>Retinal Pigment Epithelium - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - genetics</topic><topic>Rodents</topic><topic>Scavenger Receptors, Class B - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duncan, K G</creatorcontrib><creatorcontrib>Hosseini, K</creatorcontrib><creatorcontrib>Bailey, K R</creatorcontrib><creatorcontrib>Yang, H</creatorcontrib><creatorcontrib>Lowe, R J</creatorcontrib><creatorcontrib>Matthes, M T</creatorcontrib><creatorcontrib>Kane, J P</creatorcontrib><creatorcontrib>LaVail, M M</creatorcontrib><creatorcontrib>Schwartz, D M</creatorcontrib><creatorcontrib>Duncan, J L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duncan, K G</au><au>Hosseini, K</au><au>Bailey, K R</au><au>Yang, H</au><au>Lowe, R J</au><au>Matthes, M T</au><au>Kane, J P</au><au>LaVail, M M</au><au>Schwartz, D M</au><au>Duncan, J L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>93</volume><issue>8</issue><spage>1116</spage><epage>1120</epage><pages>1116-1120</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Aims:Excessive lipid accumulation in Bruch’s membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity to move lipid into BrM, mediated through ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI).Methods:ABCA1 expression was assessed by reverse transcription polymerase chain reaction (RT-PCR) and western blotting of human RPE cell extracts. Lipid transport assays were performed using radiolabelled photoreceptor outer segments (POS). ABCA1 and SR-BI expression was examined in normal mouse eyes by immunofluorescence staining. BrMs of ABCA1 and SR-BI heterozygous mice were examined microscopically.Results:Human RPE cells expressed ABCA1 mRNA and protein. The ABCA1 and SR-BI inhibitor glyburide (also known as glibenclamide) abolished basal transport of POS-derived lipids in RPE cells in the presence of high-density lipoprotein. Mouse retina and RPE expressed ABCA1 and SR-BI. SR-BI was highly expressed in RPE. BrMs were significantly thickened in SR-BI heterozygous mice, but not in ABCA1 heterozygous mice.Conclusion:RPE cells express ABCA1 and SR-BI. This implies a significant role for SR-BI and ABCA1 in lipid transport and RCT in the retina and RPE.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>19304587</pmid><doi>10.1136/bjo.2008.144006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Animals ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Bruch Membrane - ultrastructure Cells, Cultured Electroretinography Eye Proteins - metabolism Gene Expression Humans Lipid Metabolism Lipids Macular degeneration Medical sciences Mice Mice, Mutant Strains Microscopy, Electron Miscellaneous Mutation Ophthalmology Retina - metabolism Retina - physiology Retinal Pigment Epithelium - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics Rodents Scavenger Receptors, Class B - metabolism |
| title | Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium |
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