Modulating gut microbiota as an anti-diabetic mechanism of berberine
Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies. However, the mechanism of berberine's antidiabetic effect has not yet been well explained. Recent evidenc...
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| Veröffentlicht in: | Medical science monitor 2011-07, Vol.17 (7), p.RA164-RA167 |
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| creator | Han, Junling Lin, Huiling Huang, Weiping |
| description | Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies. However, the mechanism of berberine's antidiabetic effect has not yet been well explained. Recent evidence suggests that the gut microbiota composition is associated with obesity and type 2 diabetes, which are closely associated with a low-grade inflammatory state. The protective effect against diabetes of gut microbiota modulation with probiotics or antibiotics has been confirmed in recent observations. Berberine has significant antimicrobial activity against several microbes through inhibiting the assembly function of FtsZ and halting the bacteria cell division. Because berberine acts topically in the gastrointestinal tract and it is poorly absorbed, berberine might modulate gut microbiota without systemic anti-infective activity. Our hypothesis is that gut microbiota modulation may be one mechanism of the antidiabetic effect of berberine. Our hypothesis may provide a novel explanation for berberine's therapeutic effect in patients with diabetes mellitus. |
| doi_str_mv | 10.12659/msm.881842 |
| format | Article |
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However, the mechanism of berberine's antidiabetic effect has not yet been well explained. Recent evidence suggests that the gut microbiota composition is associated with obesity and type 2 diabetes, which are closely associated with a low-grade inflammatory state. The protective effect against diabetes of gut microbiota modulation with probiotics or antibiotics has been confirmed in recent observations. Berberine has significant antimicrobial activity against several microbes through inhibiting the assembly function of FtsZ and halting the bacteria cell division. Because berberine acts topically in the gastrointestinal tract and it is poorly absorbed, berberine might modulate gut microbiota without systemic anti-infective activity. Our hypothesis is that gut microbiota modulation may be one mechanism of the antidiabetic effect of berberine. Our hypothesis may provide a novel explanation for berberine's therapeutic effect in patients with diabetes mellitus.</description><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/msm.881842</identifier><identifier>PMID: 21709646</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Animals ; Berberine - pharmacology ; Berberine - therapeutic use ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - microbiology ; Gastrointestinal Tract - microbiology ; Gene Expression Regulation - drug effects ; Humans ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Medicine, Chinese Traditional ; Obesity - microbiology ; Review</subject><ispartof>Medical science monitor, 2011-07, Vol.17 (7), p.RA164-RA167</ispartof><rights>Med Sci Monit, 2011 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-a229d2e87ca7779cf66fb35b8716269f2ef5466aa0d0cae4cafcdee492e49f1f3</citedby><cites>FETCH-LOGICAL-c488t-a229d2e87ca7779cf66fb35b8716269f2ef5466aa0d0cae4cafcdee492e49f1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539561/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539561/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21709646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Junling</creatorcontrib><creatorcontrib>Lin, Huiling</creatorcontrib><creatorcontrib>Huang, Weiping</creatorcontrib><title>Modulating gut microbiota as an anti-diabetic mechanism of berberine</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies. 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Our hypothesis may provide a novel explanation for berberine's therapeutic effect in patients with diabetes mellitus.</description><subject>Animals</subject><subject>Berberine - pharmacology</subject><subject>Berberine - therapeutic use</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - microbiology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Medicine, Chinese Traditional</subject><subject>Obesity - microbiology</subject><subject>Review</subject><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1LAzEQDaLYWj15l9xla742yV4EqZ_Q4kE9h9ls0kaa3bLZCv57g9Wi8IYZmDfvMQ-hc0qmlMmyuoopTrWmWrADNKZS8IKrkhzmmXFRUELJCJ2k9E4I05KUx2jEqCKVFHKMbhdds13DENolXm4HHIPtuzp0A2BIGNqMIRRNgNoNweLo7ArakCLuPK5dnxFad4qOPKyTO_vpE_R2f_c6eyzmzw9Ps5t5YYXWQwGMVQ1zWllQSlXWS-lrXtZaUclk5ZnzpZASgDTEghMWvG2cExXL5annE3S9091s6-ga69qhh7XZ9CFC_2k6COb_pg0rs-w-DC95VUqaBS53AvnJlHrn97eUmO8wzeJlYXZhZvbFX7s99zc9_gW-6nIp</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Han, Junling</creator><creator>Lin, Huiling</creator><creator>Huang, Weiping</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110701</creationdate><title>Modulating gut microbiota as an anti-diabetic mechanism of berberine</title><author>Han, Junling ; Lin, Huiling ; Huang, Weiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-a229d2e87ca7779cf66fb35b8716269f2ef5466aa0d0cae4cafcdee492e49f1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Berberine - pharmacology</topic><topic>Berberine - therapeutic use</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - microbiology</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Medicine, Chinese Traditional</topic><topic>Obesity - microbiology</topic><topic>Review</topic><toplevel>online_resources</toplevel><creatorcontrib>Han, Junling</creatorcontrib><creatorcontrib>Lin, Huiling</creatorcontrib><creatorcontrib>Huang, Weiping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Junling</au><au>Lin, Huiling</au><au>Huang, Weiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulating gut microbiota as an anti-diabetic mechanism of berberine</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>17</volume><issue>7</issue><spage>RA164</spage><epage>RA167</epage><pages>RA164-RA167</pages><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies. However, the mechanism of berberine's antidiabetic effect has not yet been well explained. Recent evidence suggests that the gut microbiota composition is associated with obesity and type 2 diabetes, which are closely associated with a low-grade inflammatory state. The protective effect against diabetes of gut microbiota modulation with probiotics or antibiotics has been confirmed in recent observations. Berberine has significant antimicrobial activity against several microbes through inhibiting the assembly function of FtsZ and halting the bacteria cell division. Because berberine acts topically in the gastrointestinal tract and it is poorly absorbed, berberine might modulate gut microbiota without systemic anti-infective activity. Our hypothesis is that gut microbiota modulation may be one mechanism of the antidiabetic effect of berberine. 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| source | MEDLINE; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Animals Berberine - pharmacology Berberine - therapeutic use Blood Glucose - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - microbiology Gastrointestinal Tract - microbiology Gene Expression Regulation - drug effects Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Medicine, Chinese Traditional Obesity - microbiology Review |
| title | Modulating gut microbiota as an anti-diabetic mechanism of berberine |
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