Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers

Compounds that bind in the DNA minor groove have provided critical information on DNA molecular recognition, have found extensive uses in biotechnology, and are providing clinically useful drugs against diseases as diverse as cancer and sleeping sickness. This review focuses on the development of cl...

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Veröffentlicht in:	Current Protocols in Nucleic Acid Chemistry 2012-12, Vol.51 (1), p.8.8.1-8.8.20
Hauptverfasser:	Nanjunda, Rupesh, Wilson, W. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - chemistry Base Pairing Base Sequence Benzimidazoles - chemistry Binding Sites Cations, Divalent - chemistry Dimerization DNA - chemistry DNA complex structures DNA minor groove DNA, B-Form - chemistry heterocyclic amidines Heterocyclic Compounds - chemistry Models, Molecular Nucleic Acid Conformation stacked minor groove dimers surface plasmon resonance Water - chemistry
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