Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers
Compounds that bind in the DNA minor groove have provided critical information on DNA molecular recognition, have found extensive uses in biotechnology, and are providing clinically useful drugs against diseases as diverse as cancer and sleeping sickness. This review focuses on the development of cl...
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| Veröffentlicht in: | Current Protocols in Nucleic Acid Chemistry 2012-12, Vol.51 (1), p.8.8.1-8.8.20 |
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| container_title | Current Protocols in Nucleic Acid Chemistry |
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| creator | Nanjunda, Rupesh Wilson, W. David |
| description | Compounds that bind in the DNA minor groove have provided critical information on DNA molecular recognition, have found extensive uses in biotechnology, and are providing clinically useful drugs against diseases as diverse as cancer and sleeping sickness. This review focuses on the development of clinically useful heterocyclic diamidine minor groove binders. These compounds have shown us that the classical model for minor groove binding in AT DNA sequences must be expanded in several ways: compounds with nonstandard shapes can bind strongly to the groove, water can be directly incorporated into the minor groove complex in an interfacial interaction, and the compounds can form cooperative stacked dimers to recognize GC and mixed AT/GC base pair sequences. Curr. Protoc. Nucleic Acid Chem. 51:8.8.1‐8.8.20. © 2012 by John Wiley & Sons, Inc. |
| doi_str_mv | 10.1002/0471142700.nc0808s51 |
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David</creatorcontrib><title>Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers</title><title>Current Protocols in Nucleic Acid Chemistry</title><addtitle>Curr Protoc Nucleic Acid Chem</addtitle><description>Compounds that bind in the DNA minor groove have provided critical information on DNA molecular recognition, have found extensive uses in biotechnology, and are providing clinically useful drugs against diseases as diverse as cancer and sleeping sickness. This review focuses on the development of clinically useful heterocyclic diamidine minor groove binders. 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Nucleic Acid Chem. 51:8.8.1‐8.8.20. © 2012 by John Wiley & Sons, Inc.</description><subject>Amidines - chemistry</subject><subject>Base Pairing</subject><subject>Base Sequence</subject><subject>Benzimidazoles - chemistry</subject><subject>Binding Sites</subject><subject>Cations, Divalent - chemistry</subject><subject>Dimerization</subject><subject>DNA - chemistry</subject><subject>DNA complex structures</subject><subject>DNA minor groove</subject><subject>DNA, B-Form - chemistry</subject><subject>heterocyclic amidines</subject><subject>Heterocyclic Compounds - chemistry</subject><subject>Models, Molecular</subject><subject>Nucleic Acid Conformation</subject><subject>stacked minor groove dimers</subject><subject>surface plasmon resonance</subject><subject>Water - chemistry</subject><issn>1934-9270</issn><issn>1934-9289</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1OGzEUha2qqCDgDarKLxC4HttjD4tK6QSSSoRWBdaW_yaxlNiRZwBlxyP0GfsknVFKKDtW90rnnO_KPgh9JnBGAIpzYIIQVgiAs2hBgmw5-YCOSEXZqCpk9XG_CzhEp20bDAAFWsmKf0KHBS04L6A8Qt23EF2IC9wl3C09ntyM8TzElPE0p_Tosdnime98TnZrV8HiSbC6Cym2F_gqpzUe3_15_n278TY0vTpPMa19bgfctMa_vE2LGAY_fgrdsk8P6gk6aPSq9af_5jG6v7q8q2ej6x_T7_X4emSpYHJEwOpGOyOZAOGgNJpwUwoiDZEl0Y5pw4gpKtmUnmsuC2eI6N_JnCOuMZYeo6877ubBrL2zPnZZr9Qmh7XOW5V0UG-VGJZqkR4V5bQigvcAtgPYnNo2-2afJaCGItRrEWpfRB_78v_dfejl23vDxc7wFFZ--y6oqn_e1MNO_wLeEpg0</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Nanjunda, Rupesh</creator><creator>Wilson, W. 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| fulltext | fulltext |
| identifier | ISSN: 1934-9270 |
| ispartof | Current Protocols in Nucleic Acid Chemistry, 2012-12, Vol.51 (1), p.8.8.1-8.8.20 |
| issn | 1934-9270 1934-9289 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amidines - chemistry Base Pairing Base Sequence Benzimidazoles - chemistry Binding Sites Cations, Divalent - chemistry Dimerization DNA - chemistry DNA complex structures DNA minor groove DNA, B-Form - chemistry heterocyclic amidines Heterocyclic Compounds - chemistry Models, Molecular Nucleic Acid Conformation stacked minor groove dimers surface plasmon resonance Water - chemistry |
| title | Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers |
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