Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines

Yersinia pestis causes plague, a disease with high mortality in humans that can be transmitted by fleabite or aerosol. A US Food and Drug Administration (FDA)-licensed plague vaccine is currently not available. Vaccine developers have focused on two subunits of Y. pestis: LcrV, a protein at the tip...

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Veröffentlicht in:	Vaccine 2011-09, Vol.29 (38), p.6572-6583
Hauptverfasser:	Quenee, Lauriane E, Ciletti, Nancy A, Elli, Derek, Hermanas, Timothy M, Schneewind, Olaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage aerosols African Green monkeys Allergy and Immunology Aluminum aluminum hydroxide Aluminum Hydroxide - administration & dosage Animals antibodies Antibodies, Bacterial - blood antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacterial diseases Bacteriology Biological and medical sciences Cercopithecus aethiops cyclic GMP Cynomolgus Disease Models, Animal E coli fimbriae Food and Drug Administration Fundamental and applied biological sciences. Psychology Genomics GMP manufacturing good manufacturing practices Guinea Pigs Hogs Human bacterial diseases humans Immunization Infectious diseases LcrV Macaca Macaca fascicularis Macaques Manufacturing Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Monkeys & apes Mortality Pathogenesis Plague Plague - prevention & control Plague Vaccine - administration & dosage Plague Vaccine - immunology Polypeptides Primate Diseases - prevention & control Primates Protective antigen Proteins Rats Rodent Diseases - prevention & control Survival Analysis Swine Tropical bacterial diseases Type III secretion system United States Vaccination - methods Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - administration & dosage Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Yersinia pestis Yersinia pestis - genetics Yersinia pestis - immunology
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