Hepatocellular Carcinoma in Olmsted County, Minnesota, 1976-2008
Abstract Objective To analyze longitudinal trends in the incidence, etiology, and treatment of hepatocellular carcinoma (HCC) in community residents in Olmsted County, Minnesota, and their survival. Patients and Methods Olmsted County residents 20 years or older with HCC newly diagnosed from January...
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| Veröffentlicht in: | Mayo Clinic proceedings 2012, Vol.87 (1), p.9-16 |
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| creator | Yang, Ju Dong, MD, MSc Kim, Bohyun, MD, PhD Sanderson, Schuyler O., MD, MSc St. Sauver, Jennifer L., PhD Yawn, Barbara P., MD, MSc Pedersen, Rachel A., BA Larson, Joseph J., BA Therneau, Terry M., PhD Roberts, Lewis R., MBChB, PhD Kim, W. Ray, MD |
| description | Abstract Objective To analyze longitudinal trends in the incidence, etiology, and treatment of hepatocellular carcinoma (HCC) in community residents in Olmsted County, Minnesota, and their survival. Patients and Methods Olmsted County residents 20 years or older with HCC newly diagnosed from January 1, 1976, through December 31, 2008, were identified using a community-wide medical record linkage system (Rochester Epidemiology Project). The incidence rate of HCC was calculated by age and sex according to the 2000 US Census population. Temporal trends of HCC etiology, treatment, and patient survival were assessed. Results The age- and sex-adjusted incidence rate for HCC in Olmsted County was 3.5 per 100,000 person-years for the first era (1976-1990), 3.8 per 100,000 for the second era (1991-2000), and 6.9 per 100,000 for the third era (2001-2008). Alcohol use was the most common risk factor in the first and second eras and chronic hepatitis C virus in the third. The proportion attributed to nonalcoholic fatty liver disease was small (5/47 [10.6%] in the third era). Because the proportion of patients receiving curative treatment increased over time, survival also improved, with a median survival time of 3, 6, and 9 months in the first, second, and third eras, respectively ( P =.01). Conclusion In this midwestern US community, the incidence of HCC has increased, primarily due to hepatitis C virus. Although there was a demonstrable improvement in the outcome of HCC in community residents over time, the overall prognosis remains poor. |
| doi_str_mv | 10.1016/j.mayocp.2011.07.001 |
| format | Article |
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Ray, MD</creator><creatorcontrib>Yang, Ju Dong, MD, MSc ; Kim, Bohyun, MD, PhD ; Sanderson, Schuyler O., MD, MSc ; St. Sauver, Jennifer L., PhD ; Yawn, Barbara P., MD, MSc ; Pedersen, Rachel A., BA ; Larson, Joseph J., BA ; Therneau, Terry M., PhD ; Roberts, Lewis R., MBChB, PhD ; Kim, W. Ray, MD</creatorcontrib><description>Abstract Objective To analyze longitudinal trends in the incidence, etiology, and treatment of hepatocellular carcinoma (HCC) in community residents in Olmsted County, Minnesota, and their survival. Patients and Methods Olmsted County residents 20 years or older with HCC newly diagnosed from January 1, 1976, through December 31, 2008, were identified using a community-wide medical record linkage system (Rochester Epidemiology Project). The incidence rate of HCC was calculated by age and sex according to the 2000 US Census population. Temporal trends of HCC etiology, treatment, and patient survival were assessed. Results The age- and sex-adjusted incidence rate for HCC in Olmsted County was 3.5 per 100,000 person-years for the first era (1976-1990), 3.8 per 100,000 for the second era (1991-2000), and 6.9 per 100,000 for the third era (2001-2008). Alcohol use was the most common risk factor in the first and second eras and chronic hepatitis C virus in the third. The proportion attributed to nonalcoholic fatty liver disease was small (5/47 [10.6%] in the third era). Because the proportion of patients receiving curative treatment increased over time, survival also improved, with a median survival time of 3, 6, and 9 months in the first, second, and third eras, respectively ( P =.01). Conclusion In this midwestern US community, the incidence of HCC has increased, primarily due to hepatitis C virus. Although there was a demonstrable improvement in the outcome of HCC in community residents over time, the overall prognosis remains poor.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.1016/j.mayocp.2011.07.001</identifier><identifier>PMID: 22212963</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Aged ; Alcohol Drinking - adverse effects ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - therapy ; Care and treatment ; Causes of ; Diagnosis ; Female ; Health aspects ; Hepatitis C virus ; Hepatoma ; Humans ; Incidence ; Internal Medicine ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Liver Neoplasms - therapy ; Longitudinal Studies ; Male ; Medical Record Linkage ; Middle Aged ; Minnesota - epidemiology ; Original ; Risk Factors ; Survival Analysis ; Young Adult</subject><ispartof>Mayo Clinic proceedings, 2012, Vol.87 (1), p.9-16</ispartof><rights>Mayo Foundation for Medical Education and Research</rights><rights>2012 Mayo Foundation for Medical Education and Research</rights><rights>Copyright © 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.</rights><rights>COPYRIGHT 2012 Elsevier, Inc.</rights><rights>Copyright Mayo Foundation for Medical Education and Research Jan 2012</rights><rights>2012 Published by Elsevier Inc. on behalf of Mayo Foundation for Medical Education and Research. 2012 Mayo Foundation for Medical Education and Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-7cc327f2287926a9cd975b1b8afc770735055c8c4667932ff9acc62a064b43313</citedby><cites>FETCH-LOGICAL-c614t-7cc327f2287926a9cd975b1b8afc770735055c8c4667932ff9acc62a064b43313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538386/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/916019104?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,27902,27903,27904,53769,53771,64361,64363,64365,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22212963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Ju Dong, MD, MSc</creatorcontrib><creatorcontrib>Kim, Bohyun, MD, PhD</creatorcontrib><creatorcontrib>Sanderson, Schuyler O., MD, MSc</creatorcontrib><creatorcontrib>St. Sauver, Jennifer L., PhD</creatorcontrib><creatorcontrib>Yawn, Barbara P., MD, MSc</creatorcontrib><creatorcontrib>Pedersen, Rachel A., BA</creatorcontrib><creatorcontrib>Larson, Joseph J., BA</creatorcontrib><creatorcontrib>Therneau, Terry M., PhD</creatorcontrib><creatorcontrib>Roberts, Lewis R., MBChB, PhD</creatorcontrib><creatorcontrib>Kim, W. Ray, MD</creatorcontrib><title>Hepatocellular Carcinoma in Olmsted County, Minnesota, 1976-2008</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Abstract Objective To analyze longitudinal trends in the incidence, etiology, and treatment of hepatocellular carcinoma (HCC) in community residents in Olmsted County, Minnesota, and their survival. Patients and Methods Olmsted County residents 20 years or older with HCC newly diagnosed from January 1, 1976, through December 31, 2008, were identified using a community-wide medical record linkage system (Rochester Epidemiology Project). The incidence rate of HCC was calculated by age and sex according to the 2000 US Census population. Temporal trends of HCC etiology, treatment, and patient survival were assessed. Results The age- and sex-adjusted incidence rate for HCC in Olmsted County was 3.5 per 100,000 person-years for the first era (1976-1990), 3.8 per 100,000 for the second era (1991-2000), and 6.9 per 100,000 for the third era (2001-2008). Alcohol use was the most common risk factor in the first and second eras and chronic hepatitis C virus in the third. The proportion attributed to nonalcoholic fatty liver disease was small (5/47 [10.6%] in the third era). Because the proportion of patients receiving curative treatment increased over time, survival also improved, with a median survival time of 3, 6, and 9 months in the first, second, and third eras, respectively ( P =.01). Conclusion In this midwestern US community, the incidence of HCC has increased, primarily due to hepatitis C virus. Although there was a demonstrable improvement in the outcome of HCC in community residents over time, the overall prognosis remains poor.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hepatitis C virus</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - therapy</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical Record Linkage</subject><subject>Middle Aged</subject><subject>Minnesota - epidemiology</subject><subject>Original</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><subject>Young Adult</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkkFv1DAQhSMEokvhHyAUcYBLs4ztxI4viGoFFKmoB-BseZ1J14tjL3ZSaf89DluWthfkgyX7mzea96YoXhJYEiD83XY56H0wuyUFQpYglgDkUbEgsqZV09T8cbEAoE3FieQnxbOUtgAgpKyfFieUUkIlZ4viwwXu9BgMOjc5HcuVjsb6MOjS-vLKDWnErlyFyY_7s_Kr9R5TGPVZSaTgFQVonxdPeu0Svri9T4sfnz5-X11Ul1efv6zOLyvDST1WwhhGRU9pKyTlWppOimZN1q3ujRAgWANNY1pTcy4ko30vtTGcauD1umaMsNPi_UF3N60H7Az6MWqndtEOOu5V0Fbd__F2o67DjWINa1nLs8DbW4EYfk2YRjXYNM-tPYYpKUmYyK7QmXz9gNyGKfo8XYY4EEmgztDyAF1rh8r6PuSuJp8OB2uCx97m93MqWioE-dP_zZ2CDWo3blJw02iDT_fB-gCaGFKK2B-HJKDm6NVWHaJXc_QKhMrR57JXdw06Fv3N-p-DmGO6sRhVMha9wc5GNKPqgv1fh4cCxllvjXY_cY_paBJRiSpQ3-b1m7ePkLx5ULfsN6by0mc</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Yang, Ju Dong, MD, MSc</creator><creator>Kim, Bohyun, MD, PhD</creator><creator>Sanderson, Schuyler O., MD, MSc</creator><creator>St. Sauver, Jennifer L., PhD</creator><creator>Yawn, Barbara P., MD, MSc</creator><creator>Pedersen, Rachel A., BA</creator><creator>Larson, Joseph J., BA</creator><creator>Therneau, Terry M., PhD</creator><creator>Roberts, Lewis R., MBChB, PhD</creator><creator>Kim, W. Ray, MD</creator><general>Elsevier Inc</general><general>Elsevier, Inc</general><general>Elsevier Limited</general><general>Mayo Foundation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2012</creationdate><title>Hepatocellular Carcinoma in Olmsted County, Minnesota, 1976-2008</title><author>Yang, Ju Dong, MD, MSc ; Kim, Bohyun, MD, PhD ; Sanderson, Schuyler O., MD, MSc ; St. Sauver, Jennifer L., PhD ; Yawn, Barbara P., MD, MSc ; Pedersen, Rachel A., BA ; Larson, Joseph J., BA ; Therneau, Terry M., PhD ; Roberts, Lewis R., MBChB, PhD ; Kim, W. Ray, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c614t-7cc327f2287926a9cd975b1b8afc770735055c8c4667932ff9acc62a064b43313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hepatitis C virus</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - therapy</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical Record Linkage</topic><topic>Middle Aged</topic><topic>Minnesota - epidemiology</topic><topic>Original</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Ju Dong, MD, MSc</creatorcontrib><creatorcontrib>Kim, Bohyun, MD, PhD</creatorcontrib><creatorcontrib>Sanderson, Schuyler O., MD, MSc</creatorcontrib><creatorcontrib>St. Sauver, Jennifer L., PhD</creatorcontrib><creatorcontrib>Yawn, Barbara P., MD, MSc</creatorcontrib><creatorcontrib>Pedersen, Rachel A., BA</creatorcontrib><creatorcontrib>Larson, Joseph J., BA</creatorcontrib><creatorcontrib>Therneau, Terry M., PhD</creatorcontrib><creatorcontrib>Roberts, Lewis R., MBChB, PhD</creatorcontrib><creatorcontrib>Kim, W. 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Ray, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocellular Carcinoma in Olmsted County, Minnesota, 1976-2008</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>2012</date><risdate>2012</risdate><volume>87</volume><issue>1</issue><spage>9</spage><epage>16</epage><pages>9-16</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>Abstract Objective To analyze longitudinal trends in the incidence, etiology, and treatment of hepatocellular carcinoma (HCC) in community residents in Olmsted County, Minnesota, and their survival. Patients and Methods Olmsted County residents 20 years or older with HCC newly diagnosed from January 1, 1976, through December 31, 2008, were identified using a community-wide medical record linkage system (Rochester Epidemiology Project). The incidence rate of HCC was calculated by age and sex according to the 2000 US Census population. Temporal trends of HCC etiology, treatment, and patient survival were assessed. Results The age- and sex-adjusted incidence rate for HCC in Olmsted County was 3.5 per 100,000 person-years for the first era (1976-1990), 3.8 per 100,000 for the second era (1991-2000), and 6.9 per 100,000 for the third era (2001-2008). Alcohol use was the most common risk factor in the first and second eras and chronic hepatitis C virus in the third. The proportion attributed to nonalcoholic fatty liver disease was small (5/47 [10.6%] in the third era). Because the proportion of patients receiving curative treatment increased over time, survival also improved, with a median survival time of 3, 6, and 9 months in the first, second, and third eras, respectively ( P =.01). Conclusion In this midwestern US community, the incidence of HCC has increased, primarily due to hepatitis C virus. Although there was a demonstrable improvement in the outcome of HCC in community residents over time, the overall prognosis remains poor.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>22212963</pmid><doi>10.1016/j.mayocp.2011.07.001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Alcohol Drinking - adverse effects Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - therapy Care and treatment Causes of Diagnosis Female Health aspects Hepatitis C virus Hepatoma Humans Incidence Internal Medicine Liver Neoplasms - epidemiology Liver Neoplasms - etiology Liver Neoplasms - therapy Longitudinal Studies Male Medical Record Linkage Middle Aged Minnesota - epidemiology Original Risk Factors Survival Analysis Young Adult |
| title | Hepatocellular Carcinoma in Olmsted County, Minnesota, 1976-2008 |
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