eIF5A isoforms and cancer: two brothers for two functions?
Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [ N ε -(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation in the eIF5A protein in the regulation of cell proliferation and apoptosis is addressed in the present...
Gespeichert in:
| Veröffentlicht in: | Amino acids 2013-01, Vol.44 (1), p.103-109 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109 |
|---|---|
| container_issue | 1 |
| container_start_page | 103 |
| container_title | Amino acids |
| container_volume | 44 |
| creator | Caraglia, M. Park, M. H. Wolff, E. C. Marra, M. Abbruzzese, A. |
| description | Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [
N
ε
-(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation in the eIF5A protein in the regulation of cell proliferation and apoptosis is addressed in the present review. Moreover, vertebrates carry two genes that encode two eIF5A isoforms, eIF5A-1 and eIF5A-2, which, in humans, are 84% identical. However, the biological functions of these two isoforms may be significantly different. In fact, eIF5A-1 is demonstrable in most cells of different histogenesis, whereas eIF5A-2 protein is detectable only in certain human cancer cells or tissues, suggesting its role as a potential oncogene. In this review we focus our attention on the involvement of eIF5A-1 in the triggering of an apoptotic program and in the regulation of cell proliferation. In addition, the potential oncogenic role and prognostic significance of eIF5A-2 in the prediction of the survival of cancer patients is described. eIF5A-1 and/or the eIF5A-2 isoform may serve as a new molecular diagnostic or prognostic marker or as a molecular target for anti-cancer therapy. |
| doi_str_mv | 10.1007/s00726-011-1182-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3536922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4033723581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-666977f9be065df8db46a116378962cc5e56188383ff0a1e2d1efa07db9830b53</originalsourceid><addsrcrecordid>eNp1kU1LAzEQhoMotn78AC-y4MXLaibZZBMPSil-geBFzyGbTXSlTWqyq_Xfu7VVquBlAvM-806GF6EDwCeAcXma-kJ4jgFyAEHy-QYaQkFFTkDKTTTEksq8KBgM0E5KLxgDEcC30YAQoLIAMkRn9vaKjbImBRfiNGXa15nR3th4lrXvIatiaJ9tTFkvfzVc503bBJ8u9tCW05Nk91fvLnq8unwY3-R399e349FdbhiXbc45l2XpZGUxZ7UTdVVwDcBpKSQnxjDLOAhBBXUOa7CkBus0LutKCoorRnfR-dJ31lVTWxvr26gnahabqY4fKuhG_VZ886yewpuijHJJSG9wvDKI4bWzqVXTJhk7mWhvQ5cUCGBSUioW6NEf9CV00ffnKSgFlZQQvKBgSZkYUorW_XwGsFoko5bJqD4ZtUhGzfuZw_Urfia-o-gBsgRSL_knG9dW_-v6Cc5fmGc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1783932202</pqid></control><display><type>article</type><title>eIF5A isoforms and cancer: two brothers for two functions?</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Caraglia, M. ; Park, M. H. ; Wolff, E. C. ; Marra, M. ; Abbruzzese, A.</creator><creatorcontrib>Caraglia, M. ; Park, M. H. ; Wolff, E. C. ; Marra, M. ; Abbruzzese, A.</creatorcontrib><description>Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [
N
ε
-(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation in the eIF5A protein in the regulation of cell proliferation and apoptosis is addressed in the present review. Moreover, vertebrates carry two genes that encode two eIF5A isoforms, eIF5A-1 and eIF5A-2, which, in humans, are 84% identical. However, the biological functions of these two isoforms may be significantly different. In fact, eIF5A-1 is demonstrable in most cells of different histogenesis, whereas eIF5A-2 protein is detectable only in certain human cancer cells or tissues, suggesting its role as a potential oncogene. In this review we focus our attention on the involvement of eIF5A-1 in the triggering of an apoptotic program and in the regulation of cell proliferation. In addition, the potential oncogenic role and prognostic significance of eIF5A-2 in the prediction of the survival of cancer patients is described. eIF5A-1 and/or the eIF5A-2 isoform may serve as a new molecular diagnostic or prognostic marker or as a molecular target for anti-cancer therapy.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-011-1182-x</identifier><identifier>PMID: 22139412</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Amino acids ; Analytical Chemistry ; Animals ; Apoptosis ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Cancer ; Cell Transformation, Neoplastic - metabolism ; Control ; Eukaryotic Translation Initiation Factor 5A ; Gene Expression ; Human ; Humans ; Invited Review ; Life Sciences ; Lysine - analogs & derivatives ; Lysine - biosynthesis ; Markers ; Neoplasms - metabolism ; Neoplasms - pathology ; Neurobiology ; Peptide Initiation Factors - genetics ; Peptide Initiation Factors - metabolism ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; Proteins ; Proteomics ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Survival ; Translations</subject><ispartof>Amino acids, 2013-01, Vol.44 (1), p.103-109</ispartof><rights>Springer-Verlag 2011</rights><rights>Springer-Verlag Wien 2013</rights><rights>Springer-Verlag 2011 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-666977f9be065df8db46a116378962cc5e56188383ff0a1e2d1efa07db9830b53</citedby><cites>FETCH-LOGICAL-c569t-666977f9be065df8db46a116378962cc5e56188383ff0a1e2d1efa07db9830b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00726-011-1182-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00726-011-1182-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,313,314,780,784,792,885,27922,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22139412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caraglia, M.</creatorcontrib><creatorcontrib>Park, M. H.</creatorcontrib><creatorcontrib>Wolff, E. C.</creatorcontrib><creatorcontrib>Marra, M.</creatorcontrib><creatorcontrib>Abbruzzese, A.</creatorcontrib><title>eIF5A isoforms and cancer: two brothers for two functions?</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><addtitle>Amino Acids</addtitle><description>Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [
N
ε
-(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation in the eIF5A protein in the regulation of cell proliferation and apoptosis is addressed in the present review. Moreover, vertebrates carry two genes that encode two eIF5A isoforms, eIF5A-1 and eIF5A-2, which, in humans, are 84% identical. However, the biological functions of these two isoforms may be significantly different. In fact, eIF5A-1 is demonstrable in most cells of different histogenesis, whereas eIF5A-2 protein is detectable only in certain human cancer cells or tissues, suggesting its role as a potential oncogene. In this review we focus our attention on the involvement of eIF5A-1 in the triggering of an apoptotic program and in the regulation of cell proliferation. In addition, the potential oncogenic role and prognostic significance of eIF5A-2 in the prediction of the survival of cancer patients is described. eIF5A-1 and/or the eIF5A-2 isoform may serve as a new molecular diagnostic or prognostic marker or as a molecular target for anti-cancer therapy.</description><subject>Amino acids</subject><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Control</subject><subject>Eukaryotic Translation Initiation Factor 5A</subject><subject>Gene Expression</subject><subject>Human</subject><subject>Humans</subject><subject>Invited Review</subject><subject>Life Sciences</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - biosynthesis</subject><subject>Markers</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neurobiology</subject><subject>Peptide Initiation Factors - genetics</subject><subject>Peptide Initiation Factors - metabolism</subject><subject>Protein Isoforms - genetics</subject><subject>Protein Isoforms - metabolism</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Survival</subject><subject>Translations</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1LAzEQhoMotn78AC-y4MXLaibZZBMPSil-geBFzyGbTXSlTWqyq_Xfu7VVquBlAvM-806GF6EDwCeAcXma-kJ4jgFyAEHy-QYaQkFFTkDKTTTEksq8KBgM0E5KLxgDEcC30YAQoLIAMkRn9vaKjbImBRfiNGXa15nR3th4lrXvIatiaJ9tTFkvfzVc503bBJ8u9tCW05Nk91fvLnq8unwY3-R399e349FdbhiXbc45l2XpZGUxZ7UTdVVwDcBpKSQnxjDLOAhBBXUOa7CkBus0LutKCoorRnfR-dJ31lVTWxvr26gnahabqY4fKuhG_VZ886yewpuijHJJSG9wvDKI4bWzqVXTJhk7mWhvQ5cUCGBSUioW6NEf9CV00ffnKSgFlZQQvKBgSZkYUorW_XwGsFoko5bJqD4ZtUhGzfuZw_Urfia-o-gBsgRSL_knG9dW_-v6Cc5fmGc</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Caraglia, M.</creator><creator>Park, M. H.</creator><creator>Wolff, E. C.</creator><creator>Marra, M.</creator><creator>Abbruzzese, A.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>eIF5A isoforms and cancer: two brothers for two functions?</title><author>Caraglia, M. ; Park, M. H. ; Wolff, E. C. ; Marra, M. ; Abbruzzese, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-666977f9be065df8db46a116378962cc5e56188383ff0a1e2d1efa07db9830b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amino acids</topic><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biochemical Engineering</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Control</topic><topic>Eukaryotic Translation Initiation Factor 5A</topic><topic>Gene Expression</topic><topic>Human</topic><topic>Humans</topic><topic>Invited Review</topic><topic>Life Sciences</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - biosynthesis</topic><topic>Markers</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neurobiology</topic><topic>Peptide Initiation Factors - genetics</topic><topic>Peptide Initiation Factors - metabolism</topic><topic>Protein Isoforms - genetics</topic><topic>Protein Isoforms - metabolism</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>Survival</topic><topic>Translations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caraglia, M.</creatorcontrib><creatorcontrib>Park, M. H.</creatorcontrib><creatorcontrib>Wolff, E. C.</creatorcontrib><creatorcontrib>Marra, M.</creatorcontrib><creatorcontrib>Abbruzzese, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caraglia, M.</au><au>Park, M. H.</au><au>Wolff, E. C.</au><au>Marra, M.</au><au>Abbruzzese, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>eIF5A isoforms and cancer: two brothers for two functions?</atitle><jtitle>Amino acids</jtitle><stitle>Amino Acids</stitle><addtitle>Amino Acids</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>44</volume><issue>1</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [
N
ε
-(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation in the eIF5A protein in the regulation of cell proliferation and apoptosis is addressed in the present review. Moreover, vertebrates carry two genes that encode two eIF5A isoforms, eIF5A-1 and eIF5A-2, which, in humans, are 84% identical. However, the biological functions of these two isoforms may be significantly different. In fact, eIF5A-1 is demonstrable in most cells of different histogenesis, whereas eIF5A-2 protein is detectable only in certain human cancer cells or tissues, suggesting its role as a potential oncogene. In this review we focus our attention on the involvement of eIF5A-1 in the triggering of an apoptotic program and in the regulation of cell proliferation. In addition, the potential oncogenic role and prognostic significance of eIF5A-2 in the prediction of the survival of cancer patients is described. eIF5A-1 and/or the eIF5A-2 isoform may serve as a new molecular diagnostic or prognostic marker or as a molecular target for anti-cancer therapy.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>22139412</pmid><doi>10.1007/s00726-011-1182-x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-4451 |
| ispartof | Amino acids, 2013-01, Vol.44 (1), p.103-109 |
| issn | 0939-4451 1438-2199 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3536922 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amino acids Analytical Chemistry Animals Apoptosis Biochemical Engineering Biochemistry Biomedical and Life Sciences Cancer Cell Transformation, Neoplastic - metabolism Control Eukaryotic Translation Initiation Factor 5A Gene Expression Human Humans Invited Review Life Sciences Lysine - analogs & derivatives Lysine - biosynthesis Markers Neoplasms - metabolism Neoplasms - pathology Neurobiology Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Proteomics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Survival Translations |
| title | eIF5A isoforms and cancer: two brothers for two functions? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T08%3A37%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=eIF5A%20isoforms%20and%20cancer:%20two%20brothers%20for%20two%20functions?&rft.jtitle=Amino%20acids&rft.au=Caraglia,%20M.&rft.date=2013-01-01&rft.volume=44&rft.issue=1&rft.spage=103&rft.epage=109&rft.pages=103-109&rft.issn=0939-4451&rft.eissn=1438-2199&rft_id=info:doi/10.1007/s00726-011-1182-x&rft_dat=%3Cproquest_pubme%3E4033723581%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1783932202&rft_id=info:pmid/22139412&rfr_iscdi=true |