CCR5 is a receptor for Staphylococcus aureus leukotoxin ED

Pore-forming toxins are critical virulence factors for many bacterial pathogens and are central to Staphylococcus aureus- mediated killing of host cells. S. aureus encodes pore-forming bi-component leukotoxins that are toxic towards neutrophils, but also specifically target other immune cells. Despi...

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Veröffentlicht in:	Nature (London) 2013-01, Vol.493 (7430), p.51-55
Hauptverfasser:	Alonzo III, Francis, Kozhaya, Lina, Rawlings, Stephen A., Reyes-Robles, Tamara, DuMont, Ashley L., Myszka, David G., Landau, Nathaniel R., Unutmaz, Derya, Torres, Victor J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/1318 631/326/1320 631/326/41/1319 631/326/41/2534 692/700/565/1436/2185 Animals Bacterial toxins Bacterial Toxins - metabolism Bacteriology Biological and medical sciences CCR5 Receptor Antagonists Cell Death Cells, Cultured Chemokine receptors Cytotoxicity Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Exotoxins - metabolism Female Fundamental and applied biological sciences. Psychology HIV Human immunodeficiency virus Humanities and Social Sciences Humans Immune Evasion Immunologic Memory Jurkat Cells Ligands Lymphocytes Mice Microbiology Mortality multidisciplinary Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - metabolism Nosocomial infections Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Properties Receptors, CCR5 - metabolism Science Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus aureus - pathogenicity Staphylococcus infections T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Testing Toxins
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