Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets

Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it difficult to dissect how the onset of pancreatic pathology influences the emergence of CFRD. We evaluated the structure and function of the neonatal...

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Veröffentlicht in:	The Journal of clinical investigation 2012-10, Vol.122 (10), p.3755-3768
Hauptverfasser:	Olivier, Alicia K, Yi, Yaling, Sun, Xingshen, Sui, Hongshu, Liang, Bo, Hu, Shanming, Xie, Weiliang, Fisher, John T, Keiser, Nicholas W, Lei, Diana, Zhou, Weihong, Yan, Ziying, Li, Guiying, Evans, Turan I A, Meyerholz, David K, Wang, Kai, Stewart, Zoe A, Norris, Andrew W, Engelhardt, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Biomedical research Cells, Cultured - metabolism Complications and side effects Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - physiopathology Diabetes Diabetes Mellitus - blood Diabetes Mellitus - genetics Diabetes Mellitus - physiopathology Dilatation, Pathologic - genetics Dilatation, Pathologic - pathology Disease Models, Animal Disease Progression Female Ferrets - genetics Ferrets - physiology Fibrosis Gene Knockout Techniques Glucagon Glucagon - biosynthesis Glucagon - metabolism Glucose Glucose - pharmacology Glucose Intolerance - etiology Histopathology Hyperglycemia Hyperglycemia - etiology Insulin - biosynthesis Insulin - metabolism Insulin resistance Insulin Secretion Islets of Langerhans - pathology Islets of Langerhans - physiopathology Lung diseases Male Mustela Newborn babies Pancreas Pancreas, Exocrine - pathology Pancreas, Exocrine - physiopathology Pancreatic Ducts - pathology Pancreatitis - congenital Pancreatitis - genetics Pancreatitis - pathology Pancreatitis - physiopathology Pathogenesis Peptides Physiological aspects Risk factors Species Specificity Technical Advance
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