Electroporation-mediated gene delivery of cleavage-resistant pro-nerve growth factor causes retinal neuro- and vascular degeneration

Neurotrophins, including nerve growth factor (NGF), are secreted by glia as a pro-form (proNGF) that is normally cleaved into the mature ligand. Increases of proNGF has been well documented in retinal neurodegenerative diseases. Since systemic overexpression of proNGF exhibits embryonic lethality, w...

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Veröffentlicht in:	Molecular vision 2012-12, Vol.18, p.2993-3003
Hauptverfasser:	Matragoon, Suraporn, Al-Gayyar, Mohammed M H, Mysona, Barbara A, Abdelsaid, Mohammed A, Pillai, Bindu A, Neet, Kenneth E, Fagan, Susan C, El-Remessy, Azza B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Retinal Barrier - metabolism Blood-Retinal Barrier - pathology Capillary Permeability Cell Survival Electroporation Gene Expression Gene Transfer Techniques Intravitreal Injections Male Nerve Degeneration - metabolism Nerve Degeneration - pathology Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Protein Precursors - genetics Protein Precursors - metabolism Proteolysis Rats Rats, Sprague-Dawley Receptor, trkA - genetics Receptor, trkA - metabolism Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Retinal Neurons - metabolism Retinal Neurons - pathology Retinal Vessels - metabolism Retinal Vessels - pathology Transcription Factor Brn-3 - genetics Transcription Factor Brn-3 - metabolism Transgenes
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