Macrophages modulate cardiac function in lipotoxic cardiomyopathy

Diabetes is associated with myocardial lipid accumulation and an increased risk of heart failure. Although cardiac myocyte lipid overload is thought to contribute to the pathogenesis of cardiomyopathy in the setting of diabetes, the mechanism(s) through which this occurs is not well understood. Incr...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2012-12, Vol.303 (11), p.H1366-H1373
Hauptverfasser:	Schilling, Joel D, Machkovech, Heather M, Kim, Alfred H J, Schwendener, Reto, Schwedwener, Reto, Schaffer, Jean E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathies - physiopathology Cell Movement - physiology Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Cytokines - metabolism Diabetes Disease Models, Animal Heart - physiopathology Heart failure Integrative Cardiovascular Physiology and Pathophysiology Lipid Metabolism - physiology Lipids Lipids - physiology Macrophages - pathology Macrophages - physiology Mice Mice, Inbred Strains Mice, Transgenic Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Pathogenesis Risk assessment Rodents
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