In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet

Effects of low salt (LS) on (pro)renin receptor (PRR) expression are not well established. We hypothesized that LS enhances renal PRR expression via the cGMP-protein kinase G (PKG) signaling pathway. Sprague-Dawley rats were fed a normal-salt (NS) or LS diet associated with intrarenal cortical admin...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2012-12, Vol.303 (12), p.F1652-F1657
Hauptverfasser:	Matavelli, Luis C, Huang, Jiqian, Siragy, Helmy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood pressure Blood Pressure - physiology Cyclic GMP - antagonists & inhibitors Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic GMP-Dependent Protein Kinases - metabolism Diet Diet, Sodium-Restricted Enzyme Inhibitors - pharmacology Gene expression Kidney - drug effects Kidney - metabolism Male Models, Animal NG-Nitroarginine Methyl Ester - pharmacology Oxadiazoles - pharmacology Physiology Proteins Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, Cell Surface - metabolism Signal Transduction - physiology Sodium
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