Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

This study presents a new model for the regulation of nitric oxide signalling in endothelial cells; the oxidation state of endothelial haemoglobin α, controlled by cytochrome B5 reductase 3, regulates nitric oxide bioactivity and diffusion towards its vascular smooth muscle targets. Nitric oxide sig...

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Veröffentlicht in:	Nature (London) 2012-11, Vol.491 (7424), p.473-477
Hauptverfasser:	Straub, Adam C., Lohman, Alexander W., Billaud, Marie, Johnstone, Scott R., Dwyer, Scott T., Lee, Monica Y., Bortz, Pamela Schoppee, Best, Angela K., Columbus, Linda, Gaston, Benjamin, Isakson, Brant E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443 631/80/86 Adrenergic alpha-1 Receptor Agonists - pharmacology Animals Biological and medical sciences Blood vessels and receptors Cells, Cultured Cellular signal transduction Diffusion Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - metabolism Endothelium Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation - drug effects Hemoglobin Hemoglobins - genetics Hemoglobins - metabolism Humanities and Social Sciences Humans Iron - chemistry letter Mice multidisciplinary Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Observations Oxidation-Reduction Peptide Fragments - genetics Peptide Fragments - metabolism Phenylephrine - pharmacology Properties Science Signal Transduction Vertebrates: cardiovascular system
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