The Coronatine Toxin of Pseudomonas syringae Is a Multifunctional Suppressor of Arabidopsis Defense
The phytotoxin coronatine (COR) promotes various aspects of Pseudomonas syringae virulence, including invasion through stomata, growth in the apoplast, and induction of disease symptoms. COR is a structural mimic of active jasmonic acid (JA) conjugates. Known activities of COR are mediated through i...
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| Veröffentlicht in: | The Plant cell 2012-11, Vol.24 (11), p.4763-4774 |
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| container_title | The Plant cell |
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| creator | Geng, Xueqing Cheng, Jiye Gangadharan, Anju Mackey, David |
| description | The phytotoxin coronatine (COR) promotes various aspects of Pseudomonas syringae virulence, including invasion through stomata, growth in the apoplast, and induction of disease symptoms. COR is a structural mimic of active jasmonic acid (JA) conjugates. Known activities of COR are mediated through its binding to the F-box—containing JA coreceptor CORONATINE INSENSITIVE1. By analyzing the interaction of P. syringae mutants with Arabidopsis thaliana mutants, we demonstrate that, in the apoplastic space of Arabidopsis, COR is a multifunctional defense suppressor. COR and the critical P. syringae type III effector HopM1 target distinct signaling steps to suppress callose deposition. In addition to its well-documented ability to suppress salicylic acid (SA) signaling, COR suppresses an SA-independent pathway contributing to callose deposition by reducing accumulation of an indole glucosinolate upstream of the activity of the PEN2 myrosinase. COR also suppresses callose deposition and promotes bacterial growth in coi1 mutant plants, indicating that COR may have multiple targets inside plant cells. |
| doi_str_mv | 10.1105/tpc.112.105312 |
| format | Article |
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COR is a structural mimic of active jasmonic acid (JA) conjugates. Known activities of COR are mediated through its binding to the F-box—containing JA coreceptor CORONATINE INSENSITIVE1. By analyzing the interaction of P. syringae mutants with Arabidopsis thaliana mutants, we demonstrate that, in the apoplastic space of Arabidopsis, COR is a multifunctional defense suppressor. COR and the critical P. syringae type III effector HopM1 target distinct signaling steps to suppress callose deposition. In addition to its well-documented ability to suppress salicylic acid (SA) signaling, COR suppresses an SA-independent pathway contributing to callose deposition by reducing accumulation of an indole glucosinolate upstream of the activity of the PEN2 myrosinase. COR also suppresses callose deposition and promotes bacterial growth in coi1 mutant plants, indicating that COR may have multiple targets inside plant cells.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.112.105312</identifier><identifier>PMID: 23204405</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Amino Acids - metabolism ; Arabidopsis ; Arabidopsis - immunology ; Arabidopsis - microbiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Bacteria ; Cyclopentanes - metabolism ; Gene Expression Regulation, Plant ; Glucans - metabolism ; Glucosinolates ; Glucosinolates - metabolism ; Host-Pathogen Interactions ; Indenes - metabolism ; Indoles ; Indoles - metabolism ; jasmonic acid ; Leaves ; Metabolism ; Mutation ; N-Glycosyl Hydrolases - genetics ; N-Glycosyl Hydrolases - metabolism ; Oxylipins - metabolism ; Plant cells ; Plant Diseases - immunology ; Plant Diseases - microbiology ; Plant growth ; Plant Growth Regulators - metabolism ; plant hormones ; Plant Immunity ; Plants ; Pseudomonas syringae ; Pseudomonas syringae - growth & development ; Pseudomonas syringae - pathogenicity ; Pseudomonas syringae - physiology ; salicylic acid ; Salicylic Acid - metabolism ; Signal Transduction ; Virulence</subject><ispartof>The Plant cell, 2012-11, Vol.24 (11), p.4763-4774</ispartof><rights>2012 American Society of Plant Biologists</rights><rights>2012 American Society of Plant Biologists. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-13110b3bff5bae09cd7e07d990e727f1c6fe67e773d1e7696f31639734a61bb63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23327542$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23327542$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23204405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geng, Xueqing</creatorcontrib><creatorcontrib>Cheng, Jiye</creatorcontrib><creatorcontrib>Gangadharan, Anju</creatorcontrib><creatorcontrib>Mackey, David</creatorcontrib><title>The Coronatine Toxin of Pseudomonas syringae Is a Multifunctional Suppressor of Arabidopsis Defense</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>The phytotoxin coronatine (COR) promotes various aspects of Pseudomonas syringae virulence, including invasion through stomata, growth in the apoplast, and induction of disease symptoms. COR is a structural mimic of active jasmonic acid (JA) conjugates. Known activities of COR are mediated through its binding to the F-box—containing JA coreceptor CORONATINE INSENSITIVE1. By analyzing the interaction of P. syringae mutants with Arabidopsis thaliana mutants, we demonstrate that, in the apoplastic space of Arabidopsis, COR is a multifunctional defense suppressor. COR and the critical P. syringae type III effector HopM1 target distinct signaling steps to suppress callose deposition. In addition to its well-documented ability to suppress salicylic acid (SA) signaling, COR suppresses an SA-independent pathway contributing to callose deposition by reducing accumulation of an indole glucosinolate upstream of the activity of the PEN2 myrosinase. COR also suppresses callose deposition and promotes bacterial growth in coi1 mutant plants, indicating that COR may have multiple targets inside plant cells.</description><subject>Amino Acids - metabolism</subject><subject>Arabidopsis</subject><subject>Arabidopsis - immunology</subject><subject>Arabidopsis - microbiology</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Bacteria</subject><subject>Cyclopentanes - metabolism</subject><subject>Gene Expression Regulation, Plant</subject><subject>Glucans - metabolism</subject><subject>Glucosinolates</subject><subject>Glucosinolates - metabolism</subject><subject>Host-Pathogen Interactions</subject><subject>Indenes - metabolism</subject><subject>Indoles</subject><subject>Indoles - metabolism</subject><subject>jasmonic acid</subject><subject>Leaves</subject><subject>Metabolism</subject><subject>Mutation</subject><subject>N-Glycosyl Hydrolases - genetics</subject><subject>N-Glycosyl Hydrolases - metabolism</subject><subject>Oxylipins - metabolism</subject><subject>Plant cells</subject><subject>Plant Diseases - immunology</subject><subject>Plant Diseases - microbiology</subject><subject>Plant growth</subject><subject>Plant Growth Regulators - metabolism</subject><subject>plant hormones</subject><subject>Plant Immunity</subject><subject>Plants</subject><subject>Pseudomonas syringae</subject><subject>Pseudomonas syringae - growth & development</subject><subject>Pseudomonas syringae - pathogenicity</subject><subject>Pseudomonas syringae - physiology</subject><subject>salicylic acid</subject><subject>Salicylic Acid - metabolism</subject><subject>Signal Transduction</subject><subject>Virulence</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EoqVw5QbykUsWfzu5IFULtJVaFYlF4mY5zrh1lbWDnVTtf49XW6py6slPfr8ZzcxD6D0lK0qJ_DxPrgq2qppT9gIdUslZw7r298uqiSCNUJIeoDel3BBCqKbda3TAOCNCEHmI3OYa8DrlFO0cIuBNugsRJ49_FFiGtK3_BZf7HOKVBXxWsMUXyzgHv0Q3h-qO-OcyTRlKSXlXd5xtH4Y0lVDwV_AQC7xFr7wdC7x7eI_Qr-_fNuvT5vzy5Gx9fN44KcTcUF436nnvvewtkM4NGogeuo6AZtpTpzwoDVrzgYJWnfKcKt5pLqyifa_4Efqy7zst_RYGB3HOdjRTDlub702ywfzvxHBtrtKt4fV2rZK1waeHBjn9WaDMZhuKg3G0EdJSDNtdkLSsjvAcSqWkivK2Jc-jTNc4uJBtRVd71OVUSgb_ODwlZpe3qXlXwcw-71rw8enKj_i_gCvwYQ_clDnlJz5nWgrG_wK4HbDj</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Geng, Xueqing</creator><creator>Cheng, Jiye</creator><creator>Gangadharan, Anju</creator><creator>Mackey, David</creator><general>American Society of Plant Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20121101</creationdate><title>The Coronatine Toxin of Pseudomonas syringae Is a Multifunctional Suppressor of Arabidopsis Defense</title><author>Geng, Xueqing ; Cheng, Jiye ; Gangadharan, Anju ; Mackey, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-13110b3bff5bae09cd7e07d990e727f1c6fe67e773d1e7696f31639734a61bb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amino Acids - metabolism</topic><topic>Arabidopsis</topic><topic>Arabidopsis - immunology</topic><topic>Arabidopsis - microbiology</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Bacteria</topic><topic>Cyclopentanes - metabolism</topic><topic>Gene Expression Regulation, Plant</topic><topic>Glucans - metabolism</topic><topic>Glucosinolates</topic><topic>Glucosinolates - metabolism</topic><topic>Host-Pathogen Interactions</topic><topic>Indenes - metabolism</topic><topic>Indoles</topic><topic>Indoles - metabolism</topic><topic>jasmonic acid</topic><topic>Leaves</topic><topic>Metabolism</topic><topic>Mutation</topic><topic>N-Glycosyl Hydrolases - genetics</topic><topic>N-Glycosyl Hydrolases - metabolism</topic><topic>Oxylipins - metabolism</topic><topic>Plant cells</topic><topic>Plant Diseases - immunology</topic><topic>Plant Diseases - microbiology</topic><topic>Plant growth</topic><topic>Plant Growth Regulators - metabolism</topic><topic>plant hormones</topic><topic>Plant Immunity</topic><topic>Plants</topic><topic>Pseudomonas syringae</topic><topic>Pseudomonas syringae - growth & development</topic><topic>Pseudomonas syringae - pathogenicity</topic><topic>Pseudomonas syringae - physiology</topic><topic>salicylic acid</topic><topic>Salicylic Acid - metabolism</topic><topic>Signal Transduction</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geng, Xueqing</creatorcontrib><creatorcontrib>Cheng, Jiye</creatorcontrib><creatorcontrib>Gangadharan, Anju</creatorcontrib><creatorcontrib>Mackey, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geng, Xueqing</au><au>Cheng, Jiye</au><au>Gangadharan, Anju</au><au>Mackey, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Coronatine Toxin of Pseudomonas syringae Is a Multifunctional Suppressor of Arabidopsis Defense</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>24</volume><issue>11</issue><spage>4763</spage><epage>4774</epage><pages>4763-4774</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>The phytotoxin coronatine (COR) promotes various aspects of Pseudomonas syringae virulence, including invasion through stomata, growth in the apoplast, and induction of disease symptoms. COR is a structural mimic of active jasmonic acid (JA) conjugates. Known activities of COR are mediated through its binding to the F-box—containing JA coreceptor CORONATINE INSENSITIVE1. By analyzing the interaction of P. syringae mutants with Arabidopsis thaliana mutants, we demonstrate that, in the apoplastic space of Arabidopsis, COR is a multifunctional defense suppressor. COR and the critical P. syringae type III effector HopM1 target distinct signaling steps to suppress callose deposition. In addition to its well-documented ability to suppress salicylic acid (SA) signaling, COR suppresses an SA-independent pathway contributing to callose deposition by reducing accumulation of an indole glucosinolate upstream of the activity of the PEN2 myrosinase. 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| subjects | Amino Acids - metabolism Arabidopsis Arabidopsis - immunology Arabidopsis - microbiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Bacteria Cyclopentanes - metabolism Gene Expression Regulation, Plant Glucans - metabolism Glucosinolates Glucosinolates - metabolism Host-Pathogen Interactions Indenes - metabolism Indoles Indoles - metabolism jasmonic acid Leaves Metabolism Mutation N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - metabolism Oxylipins - metabolism Plant cells Plant Diseases - immunology Plant Diseases - microbiology Plant growth Plant Growth Regulators - metabolism plant hormones Plant Immunity Plants Pseudomonas syringae Pseudomonas syringae - growth & development Pseudomonas syringae - pathogenicity Pseudomonas syringae - physiology salicylic acid Salicylic Acid - metabolism Signal Transduction Virulence |
| title | The Coronatine Toxin of Pseudomonas syringae Is a Multifunctional Suppressor of Arabidopsis Defense |
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