Role of recombination activating genes in the generation of antigen receptor diversity and beyond
Summary V(D)J recombination is the process by which antibody and T‐cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non‐homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial proce...
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| Veröffentlicht in: | Immunology 2012-12, Vol.137 (4), p.271-281 |
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| container_title | Immunology |
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| creator | Nishana, Mayilaadumveettil Raghavan, Sathees C. |
| description | Summary
V(D)J recombination is the process by which antibody and T‐cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non‐homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial process of cleavage are the proteins known as RAG1 (recombination activating gene 1) and RAG2. In this review, we discuss the physiological function of RAGs as a sequence‐specific nuclease and its pathological role as a structure‐specific nuclease. The first part of the review discusses the basic mechanism of V(D)J recombination, and the last part focuses on how the RAG complex functions as a sequence‐specific and structure‐specific nuclease. It also deals with the off‐target cleavage of RAGs and its implications in genomic instability. |
| doi_str_mv | 10.1111/imm.12009 |
| format | Article |
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V(D)J recombination is the process by which antibody and T‐cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non‐homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial process of cleavage are the proteins known as RAG1 (recombination activating gene 1) and RAG2. In this review, we discuss the physiological function of RAGs as a sequence‐specific nuclease and its pathological role as a structure‐specific nuclease. The first part of the review discusses the basic mechanism of V(D)J recombination, and the last part focuses on how the RAG complex functions as a sequence‐specific and structure‐specific nuclease. It also deals with the off‐target cleavage of RAGs and its implications in genomic instability.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1111/imm.12009</identifier><identifier>PMID: 23039142</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>altered DNA structures ; Animals ; Antibodies - genetics ; Antibodies - metabolism ; Antigens ; chromosomal translocation ; class switch recombination ; DNA damage ; DNA-Binding Proteins - genetics ; double‐strand break ; Genes ; Genes, RAG-1 - physiology ; Genetic Variation ; genomic instability ; Humans ; non‐homologous DNA end joining ; Receptors, Antigen, T-Cell - genetics ; Receptors, Antigen, T-Cell - metabolism ; recombination activating gene ; Review ; T cell receptors ; V(D)J Recombination - genetics</subject><ispartof>Immunology, 2012-12, Vol.137 (4), p.271-281</ispartof><rights>2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd</rights><rights>2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd.</rights><rights>Copyright © 2012 Blackwell Publishing Ltd</rights><rights>Copyright © 2012 Blackwell Publishing Ltd 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5429-c3f93c26846805e1c87489b8ead5149e13e52dc64874c8a8769b90e6e340b2db3</citedby><cites>FETCH-LOGICAL-c5429-c3f93c26846805e1c87489b8ead5149e13e52dc64874c8a8769b90e6e340b2db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530083/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530083/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23039142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishana, Mayilaadumveettil</creatorcontrib><creatorcontrib>Raghavan, Sathees C.</creatorcontrib><title>Role of recombination activating genes in the generation of antigen receptor diversity and beyond</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Summary
V(D)J recombination is the process by which antibody and T‐cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non‐homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial process of cleavage are the proteins known as RAG1 (recombination activating gene 1) and RAG2. In this review, we discuss the physiological function of RAGs as a sequence‐specific nuclease and its pathological role as a structure‐specific nuclease. The first part of the review discusses the basic mechanism of V(D)J recombination, and the last part focuses on how the RAG complex functions as a sequence‐specific and structure‐specific nuclease. It also deals with the off‐target cleavage of RAGs and its implications in genomic instability.</description><subject>altered DNA structures</subject><subject>Animals</subject><subject>Antibodies - genetics</subject><subject>Antibodies - metabolism</subject><subject>Antigens</subject><subject>chromosomal translocation</subject><subject>class switch recombination</subject><subject>DNA damage</subject><subject>DNA-Binding Proteins - genetics</subject><subject>double‐strand break</subject><subject>Genes</subject><subject>Genes, RAG-1 - physiology</subject><subject>Genetic Variation</subject><subject>genomic instability</subject><subject>Humans</subject><subject>non‐homologous DNA end joining</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>recombination activating gene</subject><subject>Review</subject><subject>T cell receptors</subject><subject>V(D)J Recombination - genetics</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVoaFy3h_yBsNBLe9hE3ytdCsH0I5BQCOlZaLVjR2FXcqS1i_995WwakkCpLtKMnnlnpBehY4JPSVlnfhhOCcVYH6AZYVLUVMjmDZphTHRNFRZH6F3OdyVkWIi36IgyzDThdIbsdeyhissqgYtD64MdfQyVdaPflmNYVSsIkCsfqvEWHoI0IaXGhtGXzL4W1mNMVee3kLIfd-Wqq1rYxdC9R4dL22f48LjP0a9vX28WP-rLn98vFueXtROc6tqxpWaOSsVlGRiIUw1XulVgO0G4BsJA0M5JXvJOWdVI3WoMEhjHLe1aNkdfJt31ph2gcxDGZHuzTn6waWei9eblTfC3ZhW3hgmGsWJF4NOjQIr3G8ijGXx20Pc2QNxkQ6hoGt4ITv6PEiU1Z0rsVT--Qu_iJoXyE4Y0Upa-qjSfo88T5VLMOcHyaW6Czd5jUzw2Dx4X9uT5Q5_Iv6YW4GwCfvsedv9WMhdXV5PkH5MSsMs</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Nishana, Mayilaadumveettil</creator><creator>Raghavan, Sathees C.</creator><general>Wiley Subscription Services, Inc</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201212</creationdate><title>Role of recombination activating genes in the generation of antigen receptor diversity and beyond</title><author>Nishana, Mayilaadumveettil ; Raghavan, Sathees C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5429-c3f93c26846805e1c87489b8ead5149e13e52dc64874c8a8769b90e6e340b2db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>altered DNA structures</topic><topic>Animals</topic><topic>Antibodies - genetics</topic><topic>Antibodies - metabolism</topic><topic>Antigens</topic><topic>chromosomal translocation</topic><topic>class switch recombination</topic><topic>DNA damage</topic><topic>DNA-Binding Proteins - genetics</topic><topic>double‐strand break</topic><topic>Genes</topic><topic>Genes, RAG-1 - physiology</topic><topic>Genetic Variation</topic><topic>genomic instability</topic><topic>Humans</topic><topic>non‐homologous DNA end joining</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>recombination activating gene</topic><topic>Review</topic><topic>T cell receptors</topic><topic>V(D)J Recombination - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishana, Mayilaadumveettil</creatorcontrib><creatorcontrib>Raghavan, Sathees C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishana, Mayilaadumveettil</au><au>Raghavan, Sathees C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of recombination activating genes in the generation of antigen receptor diversity and beyond</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2012-12</date><risdate>2012</risdate><volume>137</volume><issue>4</issue><spage>271</spage><epage>281</epage><pages>271-281</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
V(D)J recombination is the process by which antibody and T‐cell receptor diversity is attained. During this process, antigen receptor gene segments are cleaved and rejoined by non‐homologous DNA end joining for the generation of combinatorial diversity. The major players of the initial process of cleavage are the proteins known as RAG1 (recombination activating gene 1) and RAG2. In this review, we discuss the physiological function of RAGs as a sequence‐specific nuclease and its pathological role as a structure‐specific nuclease. The first part of the review discusses the basic mechanism of V(D)J recombination, and the last part focuses on how the RAG complex functions as a sequence‐specific and structure‐specific nuclease. It also deals with the off‐target cleavage of RAGs and its implications in genomic instability.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>23039142</pmid><doi>10.1111/imm.12009</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | altered DNA structures Animals Antibodies - genetics Antibodies - metabolism Antigens chromosomal translocation class switch recombination DNA damage DNA-Binding Proteins - genetics double‐strand break Genes Genes, RAG-1 - physiology Genetic Variation genomic instability Humans non‐homologous DNA end joining Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism recombination activating gene Review T cell receptors V(D)J Recombination - genetics |
| title | Role of recombination activating genes in the generation of antigen receptor diversity and beyond |
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