MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer

The miR-106b-25 microRNA (miRNA) cluster is a candidate oncogene in human prostate cancer. Here, we report that miRNAs encoded by miR-106b-25 are upregulated in both primary tumors and distant metastasis. Moreover, increased tumor miR-106b expression was associated with disease recurrence and the co...

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Veröffentlicht in:	Oncogene 2013-08, Vol.32 (35), p.4139-4147
Hauptverfasser:	Hudson, R S, Yi, M, Esposito, D, Glynn, S A, Starks, A M, Yang, Y, Schetter, A J, Watkins, S K, Hurwitz, A A, Dorsey, T H, Stephens, R M, Croce, C M, Ambs, S
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 631/337/384/331 631/67/395 631/80/86 692/699/67/589/466 Apoptosis Bioinformatics Bone matrix Caspase 7 - genetics Caspase-7 Cell adhesion & migration Cell Biology Cell Line, Tumor Diseases Extracellular Matrix - metabolism Filaments Focal Adhesions Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Human Genetics Humans Internal Medicine Male Medicine Medicine & Public Health Metastases MicroRNA MicroRNAs MicroRNAs - physiology miRNA Neoplasm Metastasis Neoplasm Recurrence, Local - etiology Oncology original-article Phenotypes Prostate cancer Prostatic Neoplasms - etiology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Relapse Risk factors Tumors
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