Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge

Immune recognition of tumors can limit cancer development, but antitumor immune responses are often blocked by tumor-mediated immunosuppression. Because microbes or microbial constituents are powerful adjuvants to stimulate immune responses, we evaluated whether intratumoral administration of a high...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-01, Vol.190 (1), p.469-478
Hauptverfasser:	Baird, Jason R, Byrne, Katelyn T, Lizotte, Patrick H, Toraya-Brown, Seiko, Scarlett, Uciane K, Alexander, Matthew P, Sheen, Mee Rie, Fox, Barbara A, Bzik, David J, Bosenberg, Marcus, Mullins, David W, Turk, Mary Jo, Fiering, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - therapeutic use Animals Cancer Vaccines - administration & dosage Cancer Vaccines - immunology Cell Line, Tumor Injections, Intradermal Melanoma, Experimental - immunology Melanoma, Experimental - prevention & control Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Mice, SCID Mice, Transgenic Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - prevention & control Skin Neoplasms - immunology Skin Neoplasms - prevention & control Toxoplasma - immunology Toxoplasma gondii Tumor Escape - immunology Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology
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