Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8

With the majority of HIV infections resulting from mucosal transmission, induction of an effective mucosal immune response is thought to be pivotal in preventing transmission. HIV-specific IgA, but not IgG, has been detected in the genital tract, seminal fluid, urethral swabs, urine, and vaginal was...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-01, Vol.190 (1), p.205-210
Hauptverfasser:	Yu, Xiaocong, Duval, Mark, Lewis, Christopher, Gawron, Melissa A, Wang, Rijian, Posner, Marshall R, Cavacini, Lisa A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - physiology Binding Sites, Antibody HIV Antibodies - chemistry HIV Antibodies - metabolism HIV Antibodies - physiology HIV-1 - chemistry HIV-1 - immunology HIV-1 - metabolism Human immunodeficiency virus 1 Humans Immunoglobulin A - physiology Immunoglobulin Constant Regions - chemistry Immunoglobulin Constant Regions - metabolism Immunoglobulin Constant Regions - physiology Immunoglobulin Isotypes - chemistry Immunoglobulin Isotypes - metabolism Immunoglobulin Isotypes - physiology Neutralization Tests
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