Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance

Abstract Objective Insulin resistance (IR) and cardiovascular disease (CVD) share a common soil. We investigated the combined role of single nucleotide polymorphisms (SNPs) affecting insulin signaling ( ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on CVD, age at myocardial i...

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Veröffentlicht in:	Atherosclerosis 2013-01, Vol.226 (1), p.140-145
Hauptverfasser:	Bacci, Simonetta, Prudente, Sabrina, Copetti, Massimiliano, Spoto, Belinda, Rizza, Stefano, Baratta, Roberto, Di Pietro, Natalia, Morini, Eleonora, Di Paola, Rosa, Testa, Alessandra, Mallamaci, Francesca, Tripepi, Giovanni, Zhang, Yuan-Yuan, Mercuri, Luana, Di Silvestre, Sara, Lauro, Renato, Malatino, Lorenzo, Consoli, Agostino, Pellegrini, Fabio, Pandolfi, Assunta, Frittitta, Lucia, Zoccali, Carmine, Federici, Massimo, Doria, Alessandro, Trischitta, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular Diseases - genetics Cardiovascular system Cells, Cultured Cross-Sectional Studies Endothelial Cells - metabolism Endothelium, Vascular - metabolism Female Genetic susceptibility Humans Insulin - genetics Insulin dependent endothelial function Insulin Resistance - genetics Insulin sensitivity Male Medical sciences Nonsynonymous polymorphism Pharmacology. Drug treatments Prospective Studies Signal Transduction - genetics Vasodilator agents. Cerebral vasodilators
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