Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246, and CMX001

Progressive vaccinia (PV) is a rare but potentially lethal complication that develops in smallpox vaccine recipients with severely impaired cellular immunity. We describe a patient with PV who required treatment with vaccinia immune globulin and who received 2 investigational agents, ST-246 and CMX0...

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Veröffentlicht in:	The Journal of infectious diseases 2012-11, Vol.206 (9), p.1372-1385
Hauptverfasser:	Lederman, Edith R., Davidson, Whitni, Groff, Harold L., Smith, Scott K., Warkentien, Tyler, Li, Yu, Wilkins, Kimberly A., Karem, Kevin L., Akondy, Rama S., Ahmed, Rafi, Frace, Michael, Shieh, Wun-Ju, Zaki, Sherif, Hruby, Dennis E., Painter, Wendy P., Bergman, Kimberly L., Cohen, Jeffrey I., Damon, Inger K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Viral - administration & dosage Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Benzamides - administration & dosage Biological and medical sciences Cytosine - administration & dosage Cytosine - analogs & derivatives Drug Resistance, Viral Fundamental and applied biological sciences. Psychology Humans Immunoglobulins - administration & dosage Infections Infectious diseases Isoindoles - administration & dosage Lesions Lymphocytes Major and Brief Reports Male Medical sciences Microbiology Organophosphonates - administration & dosage Orthopoxvirus Smallpox Smallpox Vaccine - administration & dosage Smallpox Vaccine - adverse effects T lymphocytes Treatment Outcome Vaccination Vaccinia Vaccinia - diagnosis Vaccinia - drug therapy Vaccinia virus Vaccinia virus - isolation & purification Viruses
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