Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors

BACKGROUND. Osteosarcoma cell lines and tumors have been shown to express epidermal growth factor receptor (EGFR) and harbor amplifications at the EGFR locus. In this study, the authors further analyzed the genomic features of EGFR in osteosarcoma tumors and investigated whether they correlate with...

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Veröffentlicht in:	Cancer 2008-09, Vol.113 (6), p.1453-1461
Hauptverfasser:	Freeman, Serena S., Allen, Steven W., Ganti, Ramapriya, Wu, Jianrong, Ma, Jing, Su, Xiaoping, Neale, Geoff, Dome, Jeffrey S., Daw, Najat C., Khoury, Joseph D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Child Child, Preschool childhood cancer Diseases of the osteoarticular system EGFRvIII epidermal growth factor receptor Female Gene Amplification Gene Dosage Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques In Situ Hybridization, Fluorescence Male Medical sciences Mutation - genetics osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Polymorphism, Single Nucleotide Prognosis PTEN PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism single nucleotide polymorphism array Survival Rate Tumors Tumors of striated muscle and skeleton tyrosine kinase
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