Glucose Intolerance and Lipid Metabolic Adaptations in Response to Intrauterine and Postnatal Calorie Restriction in Male Adult Rats

Enhanced de novo lipogenesis (DNL), an adult hepatic adaption, is seen with high carbohydrate or low-fat diets. We hypothesized that ad libitum intake after prenatal calorie restriction will result in adult-onset glucose intolerance and enhanced DNL with modified lipid metabolic gene expression prof...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-01, Vol.154 (1), p.102-113
Hauptverfasser:	Garg, Meena, Thamotharan, Manikkavasagar, Dai, Yun, Lagishetty, Venu, Matveyenko, Aleksey V, Lee, W. N. Paul, Devaskar, Sherin U
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA carboxylase Acetyl-CoA Carboxylase - genetics Acetyl-CoA Carboxylase - metabolism Adipose tissue Adipose Tissue, White - metabolism Animals Animals, Newborn Beta cells Biological and medical sciences Biomarkers Blood Glucose - metabolism Blotting, Western Caloric Restriction Carbohydrates Chromatography, Gas Clearances Diabetes-Insulin-Glucagon-Gastrointestinal Diabetes. Impaired glucose tolerance Dietary restrictions Drinking - genetics Drinking - physiology Eating - genetics Eating - physiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty-acid synthase Female Fundamental and applied biological sciences. Psychology Gene expression Glucose Glucose - metabolism Glucose Intolerance - blood Glucose Intolerance - metabolism Glucose tolerance Glucose transporter Hepatocytes High carbohydrate diet High fat diet Hypocaloric diet Insulin Insulin - metabolism Insulin secretion Intolerance Isotopes Lipid Metabolism - physiology Lipids Lipogenesis Liver Low carbohydrate diet Low fat diet Male Males Mass Spectrometry Medical sciences Metabolism Nutrient deficiency Offspring Phenotypes Postpartum period Protein transport Proteins Rats Rats, Sprague-Dawley Receptors Reverse Transcriptase Polymerase Chain Reaction Stable isotopes Vertebrates: endocrinology
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