High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial
We aimed to compare the effect of 12-week feeding of commercially available infant formulas with different percentages of palmitic acid at sn -2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) form...
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creator | Litmanovitz, Ita Davidson, Keren Eliakim, Alon Regev, Rivka H. Dolfin, Tzipora Arnon, Shmuel Bar-Yoseph, Fabiana Goren, Amit Lifshitz, Yael Nemet, Dan |
description | We aimed to compare the effect of 12-week feeding of commercially available infant formulas with different percentages of palmitic acid at
sn
-2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) formula will enhance their bone speed of sound (SOS). Eighty-three infants appropriate for gestational age participated in the study; of these, 58 were formula-fed and 25 breast-fed infants, serving as a reference group. The formula-fed infants were randomly assigned to receive HBP formula (43 % of the palmitic acid is esterified to the middle position of the glycerol backbone, study group;
n
= 30) or regular formula with low-beta palmitate (LBP, 14 % of the palmitic acid is esterified to the middle position of the glycerol backbone,
n
= 28). Sixty-six infants completed the 12-week study. Anthropometric and quantitative ultrasound measurements of bone SOS for assessment of bone strength were performed at randomization and at 6 and 12 weeks postnatal age. At randomization, gestational age, birth weight, and bone SOS were comparable between the three groups. At 12 weeks postnatal age, the mean bone SOS of the HBP group was significantly higher than that of the LBP group (2,896 ± 133 vs. 2,825 ± 79 m/s respectively,
P
= 0.049) and comparable with that of the breast-fed group (2,875 ± 85 m/s). We concluded that infants consuming HBP formula had changes in bone SOS that were comparable to those of infants consuming breast milk and favorable compared to infants consuming LBP formula. |
doi_str_mv | 10.1007/s00223-012-9664-8 |
format | Article |
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sn
-2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) formula will enhance their bone speed of sound (SOS). Eighty-three infants appropriate for gestational age participated in the study; of these, 58 were formula-fed and 25 breast-fed infants, serving as a reference group. The formula-fed infants were randomly assigned to receive HBP formula (43 % of the palmitic acid is esterified to the middle position of the glycerol backbone, study group;
n
= 30) or regular formula with low-beta palmitate (LBP, 14 % of the palmitic acid is esterified to the middle position of the glycerol backbone,
n
= 28). Sixty-six infants completed the 12-week study. Anthropometric and quantitative ultrasound measurements of bone SOS for assessment of bone strength were performed at randomization and at 6 and 12 weeks postnatal age. At randomization, gestational age, birth weight, and bone SOS were comparable between the three groups. At 12 weeks postnatal age, the mean bone SOS of the HBP group was significantly higher than that of the LBP group (2,896 ± 133 vs. 2,825 ± 79 m/s respectively,
P
= 0.049) and comparable with that of the breast-fed group (2,875 ± 85 m/s). We concluded that infants consuming HBP formula had changes in bone SOS that were comparable to those of infants consuming breast milk and favorable compared to infants consuming LBP formula.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-012-9664-8</identifier><identifier>PMID: 23179103</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Age ; Anthropometry - methods ; Baby foods ; Biochemistry ; Biomedical and Life Sciences ; Birth weight ; Bone and Bones - drug effects ; Bone and Bones - physiology ; Bone density ; Bone Development - drug effects ; Bone strength ; Breast Feeding ; Breast milk ; Breastfeeding & lactation ; Cell Biology ; Double-Blind Method ; Endocrinology ; Feeding ; Female ; Follow-Up Studies ; Gestational age ; Glycerol ; Humans ; Infant ; Infant Food ; Infant Formula ; Infant formulas ; Infant, Newborn ; Infants ; Life Sciences ; Male ; Original Research ; Orthopedics ; Palmitic acid ; Palmitic Acid - therapeutic use ; Time Factors ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound</subject><ispartof>Calcified tissue international, 2013-01, Vol.92 (1), p.35-41</ispartof><rights>Springer Science+Business Media New York 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-ffe39f21bf8fe858466a8484047d21b243d84068bd37ee1f9316f3b3479bb8293</citedby><cites>FETCH-LOGICAL-c503t-ffe39f21bf8fe858466a8484047d21b243d84068bd37ee1f9316f3b3479bb8293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-012-9664-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-012-9664-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23179103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Litmanovitz, Ita</creatorcontrib><creatorcontrib>Davidson, Keren</creatorcontrib><creatorcontrib>Eliakim, Alon</creatorcontrib><creatorcontrib>Regev, Rivka H.</creatorcontrib><creatorcontrib>Dolfin, Tzipora</creatorcontrib><creatorcontrib>Arnon, Shmuel</creatorcontrib><creatorcontrib>Bar-Yoseph, Fabiana</creatorcontrib><creatorcontrib>Goren, Amit</creatorcontrib><creatorcontrib>Lifshitz, Yael</creatorcontrib><creatorcontrib>Nemet, Dan</creatorcontrib><title>High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>We aimed to compare the effect of 12-week feeding of commercially available infant formulas with different percentages of palmitic acid at
sn
-2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) formula will enhance their bone speed of sound (SOS). Eighty-three infants appropriate for gestational age participated in the study; of these, 58 were formula-fed and 25 breast-fed infants, serving as a reference group. The formula-fed infants were randomly assigned to receive HBP formula (43 % of the palmitic acid is esterified to the middle position of the glycerol backbone, study group;
n
= 30) or regular formula with low-beta palmitate (LBP, 14 % of the palmitic acid is esterified to the middle position of the glycerol backbone,
n
= 28). Sixty-six infants completed the 12-week study. Anthropometric and quantitative ultrasound measurements of bone SOS for assessment of bone strength were performed at randomization and at 6 and 12 weeks postnatal age. At randomization, gestational age, birth weight, and bone SOS were comparable between the three groups. At 12 weeks postnatal age, the mean bone SOS of the HBP group was significantly higher than that of the LBP group (2,896 ± 133 vs. 2,825 ± 79 m/s respectively,
P
= 0.049) and comparable with that of the breast-fed group (2,875 ± 85 m/s). We concluded that infants consuming HBP formula had changes in bone SOS that were comparable to those of infants consuming breast milk and favorable compared to infants consuming LBP formula.</description><subject>Age</subject><subject>Anthropometry - methods</subject><subject>Baby foods</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Birth weight</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - physiology</subject><subject>Bone density</subject><subject>Bone Development - drug effects</subject><subject>Bone strength</subject><subject>Breast Feeding</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Cell Biology</subject><subject>Double-Blind Method</subject><subject>Endocrinology</subject><subject>Feeding</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational age</subject><subject>Glycerol</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Food</subject><subject>Infant Formula</subject><subject>Infant formulas</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Palmitic acid</subject><subject>Palmitic Acid - therapeutic use</subject><subject>Time Factors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV9rFDEUxYModq1-AF8k4IsPjubfTBIfhO5qbaGg6Aq-hczOzW5qJqnJjKCf3ixbSxUEn8LN-d1zb3IQekzJC0qIfFkIYYw3hLJGd51o1B20oIKzhigm76IFoZJWRX45Qg9KuSSEiq7r7qMjxqnUlPAF-nrmtzu8hMk2H2wY_WQnwKcpj3Ow2MYBL1ME_GnKELfTDvuI15BHfB6djVN5hU_wx0ql0f-E4Tl-k-Y-QLMMPtZqleKUUwgw4HX2NjxE95wNBR5dn8fo8-nb9eqsuXj_7nx1ctFsWsKnxjng2jHaO-VAtarubJVQggg51Fsm-FCLTvUDlwDUaU47x3supO57xTQ_Rq8PvldzP8KwgbqGDeYq-9HmHyZZb_5Uot-ZbfpueMuUbmU1eHZtkNO3GcpkRl82EIKNkOZiKNO0Y0To7j9QyVnLWsUq-vQv9DLNOdafqFTNhVMtVKXogdrkVEoGd7M3JWafujmkbmrqZp-62fc8uf3gm47fMVeAHYBSpbiFfGv0P11_AXbMtlI</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Litmanovitz, Ita</creator><creator>Davidson, Keren</creator><creator>Eliakim, Alon</creator><creator>Regev, Rivka H.</creator><creator>Dolfin, Tzipora</creator><creator>Arnon, Shmuel</creator><creator>Bar-Yoseph, Fabiana</creator><creator>Goren, Amit</creator><creator>Lifshitz, Yael</creator><creator>Nemet, Dan</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial</title><author>Litmanovitz, Ita ; Davidson, Keren ; Eliakim, Alon ; Regev, Rivka H. ; Dolfin, Tzipora ; Arnon, Shmuel ; Bar-Yoseph, Fabiana ; Goren, Amit ; Lifshitz, Yael ; Nemet, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-ffe39f21bf8fe858466a8484047d21b243d84068bd37ee1f9316f3b3479bb8293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Anthropometry - methods</topic><topic>Baby foods</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Birth weight</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - physiology</topic><topic>Bone density</topic><topic>Bone Development - drug effects</topic><topic>Bone strength</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Cell Biology</topic><topic>Double-Blind Method</topic><topic>Endocrinology</topic><topic>Feeding</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational age</topic><topic>Glycerol</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Food</topic><topic>Infant Formula</topic><topic>Infant formulas</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Palmitic acid</topic><topic>Palmitic Acid - therapeutic use</topic><topic>Time Factors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Litmanovitz, Ita</creatorcontrib><creatorcontrib>Davidson, Keren</creatorcontrib><creatorcontrib>Eliakim, Alon</creatorcontrib><creatorcontrib>Regev, Rivka H.</creatorcontrib><creatorcontrib>Dolfin, Tzipora</creatorcontrib><creatorcontrib>Arnon, Shmuel</creatorcontrib><creatorcontrib>Bar-Yoseph, Fabiana</creatorcontrib><creatorcontrib>Goren, Amit</creatorcontrib><creatorcontrib>Lifshitz, Yael</creatorcontrib><creatorcontrib>Nemet, Dan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Litmanovitz, Ita</au><au>Davidson, Keren</au><au>Eliakim, Alon</au><au>Regev, Rivka H.</au><au>Dolfin, Tzipora</au><au>Arnon, Shmuel</au><au>Bar-Yoseph, Fabiana</au><au>Goren, Amit</au><au>Lifshitz, Yael</au><au>Nemet, Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>92</volume><issue>1</issue><spage>35</spage><epage>41</epage><pages>35-41</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>We aimed to compare the effect of 12-week feeding of commercially available infant formulas with different percentages of palmitic acid at
sn
-2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) formula will enhance their bone speed of sound (SOS). Eighty-three infants appropriate for gestational age participated in the study; of these, 58 were formula-fed and 25 breast-fed infants, serving as a reference group. The formula-fed infants were randomly assigned to receive HBP formula (43 % of the palmitic acid is esterified to the middle position of the glycerol backbone, study group;
n
= 30) or regular formula with low-beta palmitate (LBP, 14 % of the palmitic acid is esterified to the middle position of the glycerol backbone,
n
= 28). Sixty-six infants completed the 12-week study. Anthropometric and quantitative ultrasound measurements of bone SOS for assessment of bone strength were performed at randomization and at 6 and 12 weeks postnatal age. At randomization, gestational age, birth weight, and bone SOS were comparable between the three groups. At 12 weeks postnatal age, the mean bone SOS of the HBP group was significantly higher than that of the LBP group (2,896 ± 133 vs. 2,825 ± 79 m/s respectively,
P
= 0.049) and comparable with that of the breast-fed group (2,875 ± 85 m/s). We concluded that infants consuming HBP formula had changes in bone SOS that were comparable to those of infants consuming breast milk and favorable compared to infants consuming LBP formula.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23179103</pmid><doi>10.1007/s00223-012-9664-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Age Anthropometry - methods Baby foods Biochemistry Biomedical and Life Sciences Birth weight Bone and Bones - drug effects Bone and Bones - physiology Bone density Bone Development - drug effects Bone strength Breast Feeding Breast milk Breastfeeding & lactation Cell Biology Double-Blind Method Endocrinology Feeding Female Follow-Up Studies Gestational age Glycerol Humans Infant Infant Food Infant Formula Infant formulas Infant, Newborn Infants Life Sciences Male Original Research Orthopedics Palmitic acid Palmitic Acid - therapeutic use Time Factors Ultrasonic imaging Ultrasonography - methods Ultrasound |
title | High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial |
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