High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial

We aimed to compare the effect of 12-week feeding of commercially available infant formulas with different percentages of palmitic acid at sn -2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) form...

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Veröffentlicht in:Calcified tissue international 2013-01, Vol.92 (1), p.35-41
Hauptverfasser: Litmanovitz, Ita, Davidson, Keren, Eliakim, Alon, Regev, Rivka H., Dolfin, Tzipora, Arnon, Shmuel, Bar-Yoseph, Fabiana, Goren, Amit, Lifshitz, Yael, Nemet, Dan
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container_start_page 35
container_title Calcified tissue international
container_volume 92
creator Litmanovitz, Ita
Davidson, Keren
Eliakim, Alon
Regev, Rivka H.
Dolfin, Tzipora
Arnon, Shmuel
Bar-Yoseph, Fabiana
Goren, Amit
Lifshitz, Yael
Nemet, Dan
description We aimed to compare the effect of 12-week feeding of commercially available infant formulas with different percentages of palmitic acid at sn -2 (beta-palmitate) on anthropometric measures and bone strength of term infants. It was hypothesized that feeding infants with high beta-palmitate (HBP) formula will enhance their bone speed of sound (SOS). Eighty-three infants appropriate for gestational age participated in the study; of these, 58 were formula-fed and 25 breast-fed infants, serving as a reference group. The formula-fed infants were randomly assigned to receive HBP formula (43 % of the palmitic acid is esterified to the middle position of the glycerol backbone, study group; n  = 30) or regular formula with low-beta palmitate (LBP, 14 % of the palmitic acid is esterified to the middle position of the glycerol backbone, n  = 28). Sixty-six infants completed the 12-week study. Anthropometric and quantitative ultrasound measurements of bone SOS for assessment of bone strength were performed at randomization and at 6 and 12 weeks postnatal age. At randomization, gestational age, birth weight, and bone SOS were comparable between the three groups. At 12 weeks postnatal age, the mean bone SOS of the HBP group was significantly higher than that of the LBP group (2,896 ± 133 vs. 2,825 ± 79 m/s respectively, P  = 0.049) and comparable with that of the breast-fed group (2,875 ± 85 m/s). We concluded that infants consuming HBP formula had changes in bone SOS that were comparable to those of infants consuming breast milk and favorable compared to infants consuming LBP formula.
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At 12 weeks postnatal age, the mean bone SOS of the HBP group was significantly higher than that of the LBP group (2,896 ± 133 vs. 2,825 ± 79 m/s respectively, P  = 0.049) and comparable with that of the breast-fed group (2,875 ± 85 m/s). 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Davidson, Keren ; Eliakim, Alon ; Regev, Rivka H. ; Dolfin, Tzipora ; Arnon, Shmuel ; Bar-Yoseph, Fabiana ; Goren, Amit ; Lifshitz, Yael ; Nemet, Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-ffe39f21bf8fe858466a8484047d21b243d84068bd37ee1f9316f3b3479bb8293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Anthropometry - methods</topic><topic>Baby foods</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Birth weight</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - physiology</topic><topic>Bone density</topic><topic>Bone Development - drug effects</topic><topic>Bone strength</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>Breastfeeding &amp; lactation</topic><topic>Cell Biology</topic><topic>Double-Blind Method</topic><topic>Endocrinology</topic><topic>Feeding</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational age</topic><topic>Glycerol</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Food</topic><topic>Infant Formula</topic><topic>Infant formulas</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Palmitic acid</topic><topic>Palmitic Acid - therapeutic use</topic><topic>Time Factors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Litmanovitz, Ita</creatorcontrib><creatorcontrib>Davidson, Keren</creatorcontrib><creatorcontrib>Eliakim, Alon</creatorcontrib><creatorcontrib>Regev, Rivka H.</creatorcontrib><creatorcontrib>Dolfin, Tzipora</creatorcontrib><creatorcontrib>Arnon, Shmuel</creatorcontrib><creatorcontrib>Bar-Yoseph, Fabiana</creatorcontrib><creatorcontrib>Goren, Amit</creatorcontrib><creatorcontrib>Lifshitz, Yael</creatorcontrib><creatorcontrib>Nemet, Dan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; 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subjects Age
Anthropometry - methods
Baby foods
Biochemistry
Biomedical and Life Sciences
Birth weight
Bone and Bones - drug effects
Bone and Bones - physiology
Bone density
Bone Development - drug effects
Bone strength
Breast Feeding
Breast milk
Breastfeeding & lactation
Cell Biology
Double-Blind Method
Endocrinology
Feeding
Female
Follow-Up Studies
Gestational age
Glycerol
Humans
Infant
Infant Food
Infant Formula
Infant formulas
Infant, Newborn
Infants
Life Sciences
Male
Original Research
Orthopedics
Palmitic acid
Palmitic Acid - therapeutic use
Time Factors
Ultrasonic imaging
Ultrasonography - methods
Ultrasound
title High Beta-Palmitate Formula and Bone Strength in Term Infants: A Randomized, Double-Blind, Controlled Trial
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