Activation of Liver X Receptor Induces Macrophage Interleukin-5 Expression

IL-5 stimulates production of T15/EO6 IgM antibodies that can block the uptake of oxidized low density lipoprotein by macrophages, whereas a deficiency in macrophage IL-5 expression accelerates development of atherosclerosis. Liver X receptors (LXRs) are ligand-activated transcription factors that c...

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Veröffentlicht in:	The Journal of biological chemistry 2012-12, Vol.287 (52), p.43340-43350
Hauptverfasser:	Chen, Yuanli, Duan, Yajun, Kang, Yanhua, Yang, Xiaoxiao, Jiang, Meixiu, Zhang, Ling, Li, Guangliang, Yin, Zhinan, Hu, Wenquan, Dong, Pengzhi, Li, Xiaoju, Hajjar, David P., Han, Jihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - genetics Cell Line Cholesterol - genetics Cholesterol - metabolism Gene Expression Regulation Gene Knockdown Techniques Hydrocarbons, Fluorinated - pharmacology IL-5 Immunoglobulin M - biosynthesis Immunoglobulin M - genetics Interleukin-5 - biosynthesis Interleukin-5 - genetics Lipids Lipoprotein Liver X Receptors LXR Macrophages Macrophages - metabolism Macrophages - pathology Mice Mice, Knockout Orphan Nuclear Receptors - agonists Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism oxLDL Response Elements - genetics Scavenger Receptor Sulfonamides - pharmacology
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