mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end

Metazoan replication-dependent histone mRNAs are only present in S-phase, due partly to changes in their stability. These mRNAs end in a unique stem-loop (SL) that is required for both translation and cell-cycle regulation. Previous studies showed that histone mRNA degradation occurs through both 5&...

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Veröffentlicht in:	RNA (Cambridge) 2013-01, Vol.19 (1), p.1-16
Hauptverfasser:	Su, Wei, Slepenkov, Sergey V, Slevin, Michael K, Lyons, Shawn M, Ziemniak, Marcin, Kowalska, Joanna, Darzynkiewicz, Edward, Jemielity, Jacek, Marzluff, William F, Rhoads, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - physiology Deoxyadenosines - pharmacology DNA Replication - drug effects Gene Silencing HeLa Cells Histones - metabolism Humans Hydroxyurea - pharmacology Metazoa mRNA Cleavage and Polyadenylation Factors Nucleic Acid Synthesis Inhibitors - pharmacology Oligoribonucleotides - antagonists & inhibitors Oligoribonucleotides - metabolism Polynucleotide Adenylyltransferase Protein Biosynthesis RNA Stability - genetics RNA Stability - physiology RNA, Messenger - chemistry RNA, Messenger - metabolism Transduction, Genetic Uracil Nucleotides - antagonists & inhibitors Uracil Nucleotides - metabolism
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