A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium

Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochas...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2012-08, Vol.337 (6098), p.1091-1093
Hauptverfasser:	Doupé, David P., Alcolea, Maria P., Roshan, Amit, Zhang, Gen, Klein, Allon M., Simons, Benjamin D., Jones, Philip H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomarkers - analysis Biopsies Cell Differentiation - drug effects Cell division Cell Division - drug effects Cell growth Cell Proliferation - drug effects Cells Cells, Cultured Cycles Daughter cells Doxycycline - pharmacology Epithelial cells Epithelial Cells - physiology Epithelium Epithelium - drug effects Epithelium - metabolism Epithelium - physiology Esophagus Esophagus - cytology Esophagus - physiology Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - biosynthesis Histones - biosynthesis Homeostasis Islets of Langerhans Mice Mice, Inbred C57BL Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Online Progenitor cells Recombinant Fusion Proteins - biosynthesis Regeneration Repair Stem cells Stem Cells - metabolism Stem Cells - physiology Switches Vertebrates: digestive system
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