A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium
Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochas...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2012-08, Vol.337 (6098), p.1091-1093 |
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| creator | Doupé, David P. Alcolea, Maria P. Roshan, Amit Zhang, Gen Klein, Allon M. Simons, Benjamin D. Jones, Philip H. |
| description | Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool. |
| doi_str_mv | 10.1126/science.1218835 |
| format | Article |
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Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1218835</identifier><identifier>PMID: 22821983</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Biological and medical sciences ; Biomarkers - analysis ; Biopsies ; Cell Differentiation - drug effects ; Cell division ; Cell Division - drug effects ; Cell growth ; Cell Proliferation - drug effects ; Cells ; Cells, Cultured ; Cycles ; Daughter cells ; Doxycycline - pharmacology ; Epithelial cells ; Epithelial Cells - physiology ; Epithelium ; Epithelium - drug effects ; Epithelium - metabolism ; Epithelium - physiology ; Esophagus ; Esophagus - cytology ; Esophagus - physiology ; Fundamental and applied biological sciences. Psychology ; Green Fluorescent Proteins - biosynthesis ; Histones - biosynthesis ; Homeostasis ; Islets of Langerhans ; Mice ; Mice, Inbred C57BL ; Mouth. Exocrine and endocrine salivary glands. Teeth. 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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2012-08, Vol.337 (6098), p.1091-1093 |
| issn | 0036-8075 1095-9203 |
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| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Biological and medical sciences Biomarkers - analysis Biopsies Cell Differentiation - drug effects Cell division Cell Division - drug effects Cell growth Cell Proliferation - drug effects Cells Cells, Cultured Cycles Daughter cells Doxycycline - pharmacology Epithelial cells Epithelial Cells - physiology Epithelium Epithelium - drug effects Epithelium - metabolism Epithelium - physiology Esophagus Esophagus - cytology Esophagus - physiology Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - biosynthesis Histones - biosynthesis Homeostasis Islets of Langerhans Mice Mice, Inbred C57BL Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Online Progenitor cells Recombinant Fusion Proteins - biosynthesis Regeneration Repair Stem cells Stem Cells - metabolism Stem Cells - physiology Switches Vertebrates: digestive system |
| title | A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium |
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