Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale

Methylation of a CpG island is a faithful marker of silencing of its associated gene. Different approaches report the methylation status of a CpG island based on the determination of one or a few CpG sites by assuming the homogeneity of methylation along the element. This strategy is frequently appl...

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Veröffentlicht in:	Nucleic acids research 2012-12, Vol.40 (22), p.11490-11498
Hauptverfasser:	Barrera, Víctor, Peinado, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line CpG Islands Data processing Deoxyribonuclease HpaII DNA Methylation Enzymes Female Gene mapping Genetic Markers Genome, Human Genomes Genomics Genomics - methods Humans Methylation
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