Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

Despite the recent attention focused on the roles of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in the pathogenesis of type 2 diabetes, little is known about the ex vivo profile of inflammasome activation in type 2 diabetic p...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-01, Vol.62 (1), p.194-204
Hauptverfasser:	LEE, Hye-Mi, KIM, Jwa-Jin, HYUN JIN KIM, SHONG, Minho, BON JEONG KU, JO, Eun-Kyeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AMP-Activated Protein Kinases - physiology Antidiabetics Apoptosis Biological and medical sciences CARD Signaling Adaptor Proteins Care and treatment Carrier Proteins - genetics Carrier Proteins - physiology Cytokines Cytoskeletal Proteins - genetics Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diagnosis Dosage and administration Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Female Glucose Homeostasis Humans Immunology and Transplantation Inflammasomes - physiology Inflammation Insulin resistance Interleukin-1 Interleukin-18 - biosynthesis Interleukin-1beta - biosynthesis Interleukin-1beta - genetics Kinases Male Medical sciences Metformin Metformin - therapeutic use Middle Aged NLR Family, Pyrin Domain-Containing 3 Protein Obesity Pathogenesis Polypeptides Protein expression Proteins Reactive Oxygen Species - metabolism RNA, Messenger - analysis Type 2 diabetes Uric acid
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