Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release
Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson’s disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besid...
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| creator | Shi, Jing-Shan Wu, Qin Lu, Yuan-Fu Liu, Hang Wang, Yan-Ying Zhang, Feng Liu, Jie |
| description | Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson’s disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratrol is partially due to its additional neurotrophic effects. Here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (DA) neurons and further explore the role of neurotrophic factors in its actions. Results showed resveratrol produced neurotrophic effects on cultured DA neurons. Additionally, astroglia-derived neurotrophic factors release was responsible for resveratrol-mediated neurotrophic properties as evidenced by the following observations: (1) resveratrol failed to exert neurotrophic effects on DA neurons in the cultures without astroglia; (2) the astroglia-conditioned medium prepared from astroglia-enriched cultures treated with resveratrol produced neurotrophic effects in neuron-enriched cultures; (3) resveratrol increased neurotrophic factors release in the concentration- and time-dependent manners; (4) resveratrol-mediated neurotrophic effects were suppressed by blocking the action of the neurotrophic factors. Together, resveratrol could produce neurotrophic effects on DA neurons through prompting neurotrophic factors release, and these effects might open new alternative avenues for neurotrophic factor-based therapy targeting PD. |
| doi_str_mv | 10.1155/2012/937605 |
| format | Article |
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Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratrol is partially due to its additional neurotrophic effects. Here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (DA) neurons and further explore the role of neurotrophic factors in its actions. Results showed resveratrol produced neurotrophic effects on cultured DA neurons. Additionally, astroglia-derived neurotrophic factors release was responsible for resveratrol-mediated neurotrophic properties as evidenced by the following observations: (1) resveratrol failed to exert neurotrophic effects on DA neurons in the cultures without astroglia; (2) the astroglia-conditioned medium prepared from astroglia-enriched cultures treated with resveratrol produced neurotrophic effects in neuron-enriched cultures; (3) resveratrol increased neurotrophic factors release in the concentration- and time-dependent manners; (4) resveratrol-mediated neurotrophic effects were suppressed by blocking the action of the neurotrophic factors. Together, resveratrol could produce neurotrophic effects on DA neurons through prompting neurotrophic factors release, and these effects might open new alternative avenues for neurotrophic factor-based therapy targeting PD.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2012/937605</identifier><identifier>PMID: 23304227</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Astrocytes ; Brain research ; Brain-derived neurotrophic factor ; Conditioning ; Disease ; Dopamine ; Dopamine receptors ; Gene expression ; Glial cell line-derived neurotrophic factor ; Mesencephalon ; Movement disorders ; Neurodegeneration ; Neurodegenerative diseases ; Neuronal-glial interactions ; Neurons ; Neuroprotection ; Neurotrophic factors ; Parkinson's disease ; Resveratrol ; Rodents ; Wine</subject><ispartof>Evidence-based complementary and alternative medicine, 2012-01, Vol.2012 (2012), p.1-7</ispartof><rights>Copyright © 2012 Feng Zhang et al.</rights><rights>Copyright © 2012 Feng Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2012 Feng Zhang et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-a60c7b2a7a797e37935a2f4384d20340a4a134ae11cee95bb761fa284f73a2193</citedby><cites>FETCH-LOGICAL-c533t-a60c7b2a7a797e37935a2f4384d20340a4a134ae11cee95bb761fa284f73a2193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526011/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526011/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23304227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Olajide, Olumayokun A.</contributor><contributor>Olumayokun A Olajide</contributor><creatorcontrib>Shi, Jing-Shan</creatorcontrib><creatorcontrib>Wu, Qin</creatorcontrib><creatorcontrib>Lu, Yuan-Fu</creatorcontrib><creatorcontrib>Liu, Hang</creatorcontrib><creatorcontrib>Wang, Yan-Ying</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Liu, Jie</creatorcontrib><title>Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson’s disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratrol is partially due to its additional neurotrophic effects. Here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (DA) neurons and further explore the role of neurotrophic factors in its actions. Results showed resveratrol produced neurotrophic effects on cultured DA neurons. Additionally, astroglia-derived neurotrophic factors release was responsible for resveratrol-mediated neurotrophic properties as evidenced by the following observations: (1) resveratrol failed to exert neurotrophic effects on DA neurons in the cultures without astroglia; (2) the astroglia-conditioned medium prepared from astroglia-enriched cultures treated with resveratrol produced neurotrophic effects in neuron-enriched cultures; (3) resveratrol increased neurotrophic factors release in the concentration- and time-dependent manners; (4) resveratrol-mediated neurotrophic effects were suppressed by blocking the action of the neurotrophic factors. Together, resveratrol could produce neurotrophic effects on DA neurons through prompting neurotrophic factors release, and these effects might open new alternative avenues for neurotrophic factor-based therapy targeting PD.</description><subject>Astrocytes</subject><subject>Brain research</subject><subject>Brain-derived neurotrophic factor</subject><subject>Conditioning</subject><subject>Disease</subject><subject>Dopamine</subject><subject>Dopamine receptors</subject><subject>Gene expression</subject><subject>Glial cell line-derived neurotrophic factor</subject><subject>Mesencephalon</subject><subject>Movement disorders</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neuronal-glial interactions</subject><subject>Neurons</subject><subject>Neuroprotection</subject><subject>Neurotrophic factors</subject><subject>Parkinson's disease</subject><subject>Resveratrol</subject><subject>Rodents</subject><subject>Wine</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUtv1DAURi0Eog9YsUeW2CCqoX4lTjaVyvQBUtVWFUjsrDvJTeIqsYOdtGLBf6-HKaPCipWv7KOj7_oj5A1nHznPskPBuDgspc5Z9ozscq34QomieL6d9fcdshfjLWOi1Fq_JDtCSqaE0Lvk1w3GOwwwBd_T6-DrucJIL3EOPl2Nna3oadNgNUXqHV3O_TQHrOmJH2GwDkObgN-0i3Tqgp_bbq0Zxsm6lh7HJGl7Cz39dHJ5RsHV9Hw93GCPEPEVedFAH_H147lPvp2dfl1-XlxcnX9ZHl8sqkzKaQE5q_RKgAZdapS6lBmIRslC1YJJxUABlwqQ8wqxzFYrnfMGRKEaLUHwUu6To413nFcD1hW6KUBvxmAHCD-NB2v-fnG2M62_MzITOeM8Cd4_CoL_MWOczGBjhX0PDv0cDRdapjhKZwl99w966-fg0npGsJwVrEifn6iDDVUFH2PAZhuGM7Ou1axrNZtaE_32af4t-6fHBHzYAJ11Ndzb_7NhQrCBJ7AocpnLB6jqtOo</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Shi, Jing-Shan</creator><creator>Wu, Qin</creator><creator>Lu, Yuan-Fu</creator><creator>Liu, Hang</creator><creator>Wang, Yan-Ying</creator><creator>Zhang, Feng</creator><creator>Liu, Jie</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release</title><author>Shi, Jing-Shan ; Wu, Qin ; Lu, Yuan-Fu ; Liu, Hang ; Wang, Yan-Ying ; Zhang, Feng ; Liu, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-a60c7b2a7a797e37935a2f4384d20340a4a134ae11cee95bb761fa284f73a2193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Astrocytes</topic><topic>Brain research</topic><topic>Brain-derived neurotrophic factor</topic><topic>Conditioning</topic><topic>Disease</topic><topic>Dopamine</topic><topic>Dopamine receptors</topic><topic>Gene expression</topic><topic>Glial cell line-derived neurotrophic factor</topic><topic>Mesencephalon</topic><topic>Movement disorders</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neuronal-glial interactions</topic><topic>Neurons</topic><topic>Neuroprotection</topic><topic>Neurotrophic factors</topic><topic>Parkinson's disease</topic><topic>Resveratrol</topic><topic>Rodents</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Jing-Shan</creatorcontrib><creatorcontrib>Wu, Qin</creatorcontrib><creatorcontrib>Lu, Yuan-Fu</creatorcontrib><creatorcontrib>Liu, Hang</creatorcontrib><creatorcontrib>Wang, Yan-Ying</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Liu, Jie</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Jing-Shan</au><au>Wu, Qin</au><au>Lu, Yuan-Fu</au><au>Liu, Hang</au><au>Wang, Yan-Ying</au><au>Zhang, Feng</au><au>Liu, Jie</au><au>Olajide, Olumayokun A.</au><au>Olumayokun A Olajide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson’s disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratrol is partially due to its additional neurotrophic effects. Here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (DA) neurons and further explore the role of neurotrophic factors in its actions. Results showed resveratrol produced neurotrophic effects on cultured DA neurons. Additionally, astroglia-derived neurotrophic factors release was responsible for resveratrol-mediated neurotrophic properties as evidenced by the following observations: (1) resveratrol failed to exert neurotrophic effects on DA neurons in the cultures without astroglia; (2) the astroglia-conditioned medium prepared from astroglia-enriched cultures treated with resveratrol produced neurotrophic effects in neuron-enriched cultures; (3) resveratrol increased neurotrophic factors release in the concentration- and time-dependent manners; (4) resveratrol-mediated neurotrophic effects were suppressed by blocking the action of the neurotrophic factors. Together, resveratrol could produce neurotrophic effects on DA neurons through prompting neurotrophic factors release, and these effects might open new alternative avenues for neurotrophic factor-based therapy targeting PD.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>23304227</pmid><doi>10.1155/2012/937605</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection |
| subjects | Astrocytes Brain research Brain-derived neurotrophic factor Conditioning Disease Dopamine Dopamine receptors Gene expression Glial cell line-derived neurotrophic factor Mesencephalon Movement disorders Neurodegeneration Neurodegenerative diseases Neuronal-glial interactions Neurons Neuroprotection Neurotrophic factors Parkinson's disease Resveratrol Rodents Wine |
| title | Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release |
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