Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

Along with an enhanced interaction with CD4, highly M‐tropic HIV‐1 Envs have an altered mechanism of engagement with CCR5. BR‐derived HIV‐1 strains have an exceptional ability to enter macrophages via mechanisms involving their gp120 Env that remain incompletely understood. Here, we used cell‐based...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of leukocyte biology 2013-01, Vol.93 (1), p.113-126
Hauptverfasser:	Salimi, Hamid, Roche, Michael, Webb, Nicholas, Gray, Lachlan R., Chikere, Kelechi, Sterjovski, Jasminka, Ellett, Anne, Wesselingh, Steve L., Ramsland, Paul A., Lee, Benhur, Churchill, Melissa J., Gorry, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinofile Brain - virology CD4 Antigens - metabolism Cells, Cultured CNS Env Epitope Mapping HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - metabolism HIV-1 - physiology Human immunodeficiency virus 1 Humans Macrophages - virology Models, Theoretical phenotype Receptors, CCR5 - metabolism Receptors, Signal Transduction, & Genes signature Viral Tropism - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!