Plasma 25-Hydroxyvitamin D3 and Bladder Cancer Risk According to Tumor Stage and FGFR3 Status: A Mechanism- Based Epidemiological Study
Previous evidence suggests that 25-hydroxyvitamin D^sub 3^ [25(OH)D^sub 3^] protects against several cancers. However, little is known regarding urothelial bladder cancer (UBC). Amaral et al analyzed the association between plasma 25(OH)D^sub 3^ and overall risk of UBC, as well as according to stage...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2012-12, Vol.104 (24), p.1897-1904 |
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| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 104 |
| creator | AMARAL, André Fs MENDEZ-PERTUZ, Marinela REAL, Francisco X MALATS, Nuria MUNOZ, Alberto SILVERMAN, Debra T ALLORY, Yves KOGEVINAS, Manolis LLORETA, Josep ROTHMAN, Nathaniel CARRATO, Alfredo DEL FRESNO, Manuel Rivas |
| description | Previous evidence suggests that 25-hydroxyvitamin D^sub 3^ [25(OH)D^sub 3^] protects against several cancers. However, little is known regarding urothelial bladder cancer (UBC). Amaral et al analyzed the association between plasma 25(OH)D^sub 3^ and overall risk of UBC, as well as according to stage and FGFR3 molecular subphenotypes. Their findings support a role of vitamin D in the pathogenesis of UBC and show that 25(OH)D^sub 3^ levels are associated with FGFR3 expression in the tumor. Because FGFR3 mutation and overexpression are markers of better outcome, our findings suggest that individuals with low levels of plasma 25(OH)D^sub 3^ may be at high risk of more aggressive forms of UBC. |
| doi_str_mv | 10.1093/jnci/djs444 |
| format | Article |
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However, little is known regarding urothelial bladder cancer (UBC). Amaral et al analyzed the association between plasma 25(OH)D^sub 3^ and overall risk of UBC, as well as according to stage and FGFR3 molecular subphenotypes. Their findings support a role of vitamin D in the pathogenesis of UBC and show that 25(OH)D^sub 3^ levels are associated with FGFR3 expression in the tumor. Because FGFR3 mutation and overexpression are markers of better outcome, our findings suggest that individuals with low levels of plasma 25(OH)D^sub 3^ may be at high risk of more aggressive forms of UBC.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/djs444</identifier><identifier>PMID: 23108201</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Biological and medical sciences ; Bladder ; Cancer ; Epidemiology ; Medical sciences ; Nephrology. 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However, little is known regarding urothelial bladder cancer (UBC). Amaral et al analyzed the association between plasma 25(OH)D^sub 3^ and overall risk of UBC, as well as according to stage and FGFR3 molecular subphenotypes. Their findings support a role of vitamin D in the pathogenesis of UBC and show that 25(OH)D^sub 3^ levels are associated with FGFR3 expression in the tumor. Because FGFR3 mutation and overexpression are markers of better outcome, our findings suggest that individuals with low levels of plasma 25(OH)D^sub 3^ may be at high risk of more aggressive forms of UBC.</description><subject>Biological and medical sciences</subject><subject>Bladder</subject><subject>Cancer</subject><subject>Epidemiology</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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| issn | 0027-8874 1460-2105 |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Bladder Cancer Epidemiology Medical sciences Nephrology. Urinary tract diseases Tumors Tumors of the urinary system Urinary tract. Prostate gland Vitamin D |
| title | Plasma 25-Hydroxyvitamin D3 and Bladder Cancer Risk According to Tumor Stage and FGFR3 Status: A Mechanism- Based Epidemiological Study |
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