Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

Chromatin remodeling during DNA double-strand break (DSB) repair is required to facilitate access to and repair of DSBs. This remodeling requires increased acetylation of histones and a shift in nucleosome organization to create open, relaxed chromatin domains. However, the underlying mechanism driv...

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Veröffentlicht in:	Molecular cell 2012-12, Vol.48 (5), p.723-733
Hauptverfasser:	Xu, Ye, Ayrapetov, Marina K., Xu, Chang, Gursoy-Yuzugullu, Ozge, Hu, Yiduo, Price, Brendan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenosine Triphosphatases - metabolism adenosinetriphosphatase Antigens, Nuclear - metabolism Binding Sites Binding, Competitive Carrier Proteins - metabolism Chromatin Assembly and Disassembly DNA Breaks, Double-Stranded DNA End-Joining Repair DNA Repair DNA-Binding Proteins - metabolism Dose-Response Relationship, Radiation equipment maintenance and repair HEK293 Cells HeLa Cells histones Histones - chemistry Histones - genetics Histones - metabolism Humans Ku Autoantigen Nuclear Proteins - metabolism nucleases Nucleic Acid Conformation nucleosomes Nucleosomes - chemistry Nucleosomes - genetics Nucleosomes - metabolism Nucleosomes - radiation effects RNA Interference single-stranded DNA Time Factors Transfection tumor suppressor proteins Ubiquitination
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