Pyrrole-Imidazole Polyamide Targeting Transforming Growth Factor β1 Ameliorates Encapsulating Peritoneal Sclerosis

Encapsulating peritoneal sclerosis (EPS) is a devastating fibrotic complication in patients treated with peritoneal dialysis (PD). Transforming growth factor β1 (TGF-β1) is a pivotal factor in the induction of EPS. To develop pyrrole-imidazole (PI) polyamide, a novel gene silencer, targeted to the T...

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Veröffentlicht in:	Peritoneal dialysis international 2012-07, Vol.32 (4), p.462-472
Hauptverfasser:	Serie, Kazuo, Fukuda, Noboru, Nakai, Shigeki, Matsuda, Hiroyuki, Maruyama, Takashi, Murayama, Yoshinobu, Omata, Sadao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Electrophoretic Mobility Shift Assay Extracellular Matrix Gene Silencing Imidazoles - pharmacology Imidazoles - therapeutic use Male Nylons - pharmacology Original Peritoneal Dialysis - adverse effects Peritoneal Fibrosis - genetics Peritoneal Fibrosis - metabolism Peritoneum - drug effects Peritoneum - metabolism Pyrroles - pharmacology Pyrroles - therapeutic use Rats Rats, Sprague-Dawley Rats, Wistar RNA, Messenger - biosynthesis Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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