Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease
To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex, age,...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2013-01, Vol.36 (1), p.117-125 |
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| container_title | Sleep (New York, N.Y.) |
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| creator | van Wamelen, Daniel J Aziz, N Ahmad Anink, Jasper J van Steenhoven, Robin Angeloni, Debora Fraschini, Franco Jockers, Ralf Roos, Raymund A C Swaab, Dick F |
| description | To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus.
Postmortem cohort study.
Eight patients with HD and eight control subjects matched for sex, age, clock time and month of death, postmortem delay, and fixation time of paraffin-embedded hypothalamic tissue.
Using postmortem paraffin-embedded tissue, we assessed the functional integrity of the suprachiasmatic nucleus in patients with HD and control subjects by determining the expression of two major regulatory neuropeptides, vasoactive intestinal polypeptide and arginine vasopressin. Additionally, we studied melatonin 1 and 2 receptor expression. Compared with control subjects, the suprachiasmatic nucleus contained 85% fewer neurons immunoreactive for vasoactive intestinal polypeptide and 33% fewer neurons for arginine vasopressin in patients with HD (P = 0.002 and P = 0.027). The total amount of vasoactive intestinal polypeptide and arginine vasopressin messenger RNA was unchanged. No change was observed in the number of melatonin 1 or 2 receptor immunoreactive neurons.
These findings indicate posttranscriptional neuropeptide changes in the suprachiasmatic nucleus of patients with HD, and suggest that sleep and circadian rhythm disorders in these patients may at least partly arise from suprachiasmatic nucleus dysfunction. |
| doi_str_mv | 10.5665/sleep.2314 |
| format | Article |
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Postmortem cohort study.
Eight patients with HD and eight control subjects matched for sex, age, clock time and month of death, postmortem delay, and fixation time of paraffin-embedded hypothalamic tissue.
Using postmortem paraffin-embedded tissue, we assessed the functional integrity of the suprachiasmatic nucleus in patients with HD and control subjects by determining the expression of two major regulatory neuropeptides, vasoactive intestinal polypeptide and arginine vasopressin. Additionally, we studied melatonin 1 and 2 receptor expression. Compared with control subjects, the suprachiasmatic nucleus contained 85% fewer neurons immunoreactive for vasoactive intestinal polypeptide and 33% fewer neurons for arginine vasopressin in patients with HD (P = 0.002 and P = 0.027). The total amount of vasoactive intestinal polypeptide and arginine vasopressin messenger RNA was unchanged. No change was observed in the number of melatonin 1 or 2 receptor immunoreactive neurons.
These findings indicate posttranscriptional neuropeptide changes in the suprachiasmatic nucleus of patients with HD, and suggest that sleep and circadian rhythm disorders in these patients may at least partly arise from suprachiasmatic nucleus dysfunction.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.5665/sleep.2314</identifier><identifier>PMID: 23288978</identifier><language>eng</language><publisher>United States: Associated Professional Sleep Societies, LLC</publisher><subject>Arginine Vasopressin - metabolism ; Chronobiology Disorders - complications ; Chronobiology Disorders - metabolism ; Circadian Rhythm ; Cohort Studies ; Female ; Humans ; Huntington Disease - complications ; Huntington Disease - metabolism ; Hypothalamus - metabolism ; In Situ Hybridization - methods ; Male ; Neuropeptides - metabolism ; Sleep Wake Disorders - complications ; Sleep Wake Disorders - metabolism ; Suprachiasmatic Nucleus - metabolism ; Suprachiasmatic Nucleus in Huntington's Disease ; Vasoactive Intestinal Peptide - metabolism</subject><ispartof>Sleep (New York, N.Y.), 2013-01, Vol.36 (1), p.117-125</ispartof><rights>2013 Associated Professional Sleep Societies, LLC. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-28d4e3a0939c4d6d558d11c904f91b59d46077b31c09a52f56576a24d5fa8693</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23288978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Wamelen, Daniel J</creatorcontrib><creatorcontrib>Aziz, N Ahmad</creatorcontrib><creatorcontrib>Anink, Jasper J</creatorcontrib><creatorcontrib>van Steenhoven, Robin</creatorcontrib><creatorcontrib>Angeloni, Debora</creatorcontrib><creatorcontrib>Fraschini, Franco</creatorcontrib><creatorcontrib>Jockers, Ralf</creatorcontrib><creatorcontrib>Roos, Raymund A C</creatorcontrib><creatorcontrib>Swaab, Dick F</creatorcontrib><title>Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus.
Postmortem cohort study.
Eight patients with HD and eight control subjects matched for sex, age, clock time and month of death, postmortem delay, and fixation time of paraffin-embedded hypothalamic tissue.
Using postmortem paraffin-embedded tissue, we assessed the functional integrity of the suprachiasmatic nucleus in patients with HD and control subjects by determining the expression of two major regulatory neuropeptides, vasoactive intestinal polypeptide and arginine vasopressin. Additionally, we studied melatonin 1 and 2 receptor expression. Compared with control subjects, the suprachiasmatic nucleus contained 85% fewer neurons immunoreactive for vasoactive intestinal polypeptide and 33% fewer neurons for arginine vasopressin in patients with HD (P = 0.002 and P = 0.027). The total amount of vasoactive intestinal polypeptide and arginine vasopressin messenger RNA was unchanged. No change was observed in the number of melatonin 1 or 2 receptor immunoreactive neurons.
These findings indicate posttranscriptional neuropeptide changes in the suprachiasmatic nucleus of patients with HD, and suggest that sleep and circadian rhythm disorders in these patients may at least partly arise from suprachiasmatic nucleus dysfunction.</description><subject>Arginine Vasopressin - metabolism</subject><subject>Chronobiology Disorders - complications</subject><subject>Chronobiology Disorders - metabolism</subject><subject>Circadian Rhythm</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Huntington Disease - complications</subject><subject>Huntington Disease - metabolism</subject><subject>Hypothalamus - metabolism</subject><subject>In Situ Hybridization - methods</subject><subject>Male</subject><subject>Neuropeptides - metabolism</subject><subject>Sleep Wake Disorders - complications</subject><subject>Sleep Wake Disorders - metabolism</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Suprachiasmatic Nucleus in Huntington's Disease</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVtLxDAQhYMo7rr64g-QvilC11yaNnkRxDsIPrg-h2w6dSPdtGZaL__e6uqiT8MwH2cO5xCyz-hU5rk8wRqgnXLBsg0yZlLSVDOqN8mYspylilE5IjuIz3TYMy22yYgLrpQu1Jg8PvRttG7hLS5t510SeldDj0mAPjYttJ0vIYH3NgKib0LiQ9IOIIQOkzffLZKbPnQ-PHVNOMTkwiNYhF2yVdkaYe9nTsjs6nJ2fpPe3V_fnp_dpU4Uqku5KjMQlmqhXVbmpZSqZMxpmlWazaUus5wWxVwwR7WVvJK5LHLLs1JWVuVaTMjpSrbt50so3WAq2tq00S9t_DCN9eb_JfiFeWpejZA8k0IMAkc_ArF56QE7s_TooK5tgKZHw3ghOKVCqwE9XqEuNogRqvUbRs1XDea7BvNVwwAf_DW2Rn9zF58ap4Yr</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>van Wamelen, Daniel J</creator><creator>Aziz, N Ahmad</creator><creator>Anink, Jasper J</creator><creator>van Steenhoven, Robin</creator><creator>Angeloni, Debora</creator><creator>Fraschini, Franco</creator><creator>Jockers, Ralf</creator><creator>Roos, Raymund A C</creator><creator>Swaab, Dick F</creator><general>Associated Professional Sleep Societies, LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease</title><author>van Wamelen, Daniel J ; Aziz, N Ahmad ; Anink, Jasper J ; van Steenhoven, Robin ; Angeloni, Debora ; Fraschini, Franco ; Jockers, Ralf ; Roos, Raymund A C ; Swaab, Dick F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-28d4e3a0939c4d6d558d11c904f91b59d46077b31c09a52f56576a24d5fa8693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Arginine Vasopressin - metabolism</topic><topic>Chronobiology Disorders - complications</topic><topic>Chronobiology Disorders - metabolism</topic><topic>Circadian Rhythm</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Huntington Disease - complications</topic><topic>Huntington Disease - metabolism</topic><topic>Hypothalamus - metabolism</topic><topic>In Situ Hybridization - methods</topic><topic>Male</topic><topic>Neuropeptides - metabolism</topic><topic>Sleep Wake Disorders - complications</topic><topic>Sleep Wake Disorders - metabolism</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Suprachiasmatic Nucleus in Huntington's Disease</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Wamelen, Daniel J</creatorcontrib><creatorcontrib>Aziz, N Ahmad</creatorcontrib><creatorcontrib>Anink, Jasper J</creatorcontrib><creatorcontrib>van Steenhoven, Robin</creatorcontrib><creatorcontrib>Angeloni, Debora</creatorcontrib><creatorcontrib>Fraschini, Franco</creatorcontrib><creatorcontrib>Jockers, Ralf</creatorcontrib><creatorcontrib>Roos, Raymund A C</creatorcontrib><creatorcontrib>Swaab, Dick F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Wamelen, Daniel J</au><au>Aziz, N Ahmad</au><au>Anink, Jasper J</au><au>van Steenhoven, Robin</au><au>Angeloni, Debora</au><au>Fraschini, Franco</au><au>Jockers, Ralf</au><au>Roos, Raymund A C</au><au>Swaab, Dick F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>36</volume><issue>1</issue><spage>117</spage><epage>125</epage><pages>117-125</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus.
Postmortem cohort study.
Eight patients with HD and eight control subjects matched for sex, age, clock time and month of death, postmortem delay, and fixation time of paraffin-embedded hypothalamic tissue.
Using postmortem paraffin-embedded tissue, we assessed the functional integrity of the suprachiasmatic nucleus in patients with HD and control subjects by determining the expression of two major regulatory neuropeptides, vasoactive intestinal polypeptide and arginine vasopressin. Additionally, we studied melatonin 1 and 2 receptor expression. Compared with control subjects, the suprachiasmatic nucleus contained 85% fewer neurons immunoreactive for vasoactive intestinal polypeptide and 33% fewer neurons for arginine vasopressin in patients with HD (P = 0.002 and P = 0.027). The total amount of vasoactive intestinal polypeptide and arginine vasopressin messenger RNA was unchanged. No change was observed in the number of melatonin 1 or 2 receptor immunoreactive neurons.
These findings indicate posttranscriptional neuropeptide changes in the suprachiasmatic nucleus of patients with HD, and suggest that sleep and circadian rhythm disorders in these patients may at least partly arise from suprachiasmatic nucleus dysfunction.</abstract><cop>United States</cop><pub>Associated Professional Sleep Societies, LLC</pub><pmid>23288978</pmid><doi>10.5665/sleep.2314</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Sleep (New York, N.Y.), 2013-01, Vol.36 (1), p.117-125 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Arginine Vasopressin - metabolism Chronobiology Disorders - complications Chronobiology Disorders - metabolism Circadian Rhythm Cohort Studies Female Humans Huntington Disease - complications Huntington Disease - metabolism Hypothalamus - metabolism In Situ Hybridization - methods Male Neuropeptides - metabolism Sleep Wake Disorders - complications Sleep Wake Disorders - metabolism Suprachiasmatic Nucleus - metabolism Suprachiasmatic Nucleus in Huntington's Disease Vasoactive Intestinal Peptide - metabolism |
| title | Suprachiasmatic nucleus neuropeptide expression in patients with Huntington's Disease |
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