Striatal Presynaptic Dopamine in Schizophrenia, Part II: Meta-Analysis of [18F/11C]-DOPA PET Studies

Alterations in striatal dopamine neurotransmission are central to the emergence of psychotic symptoms and to the mechanism of action of antipsychotics. Although the functional integrity of the presynaptic system can be assessed by measuring striatal dopamine synthesis capacity (DSC), no quantitative...

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Veröffentlicht in:	Schizophrenia bulletin 2013-01, Vol.39 (1), p.33-42
Hauptverfasser:	FUSAR-POLI, Paolo, MEYER-LINDENBERG, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Biological and medical sciences Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Dopamine - biosynthesis Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Positron-Emission Tomography - methods Presynaptic Terminals - metabolism Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Putamen - diagnostic imaging Putamen - metabolism Regular Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Up-Regulation - physiology
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