Regulation of inflammasome signaling
Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1β (IL-1β), IL-18 and pyroptosis. Inflammasomes recognize microbial products or e...
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| Veröffentlicht in: | Nature immunology 2012-04, Vol.13 (4), p.333-342 |
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| container_title | Nature immunology |
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| creator | Rathinam, Vijay A K Vanaja, Sivapriya Kailasan Fitzgerald, Katherine A |
| description | Innate immune responses have the ability to both combat infectious microbes and drive pathological inflammation. Inflammasome complexes are a central component of these processes through their regulation of interleukin 1β (IL-1β), IL-18 and pyroptosis. Inflammasomes recognize microbial products or endogenous molecules released from damaged or dying cells both through direct binding of ligands and indirect mechanisms. The potential of the IL-1 family of cytokines to cause tissue damage and chronic inflammation emphasizes the importance of regulating inflammasomes. Many regulatory mechanisms have been identified that act as checkpoints for attenuating inflammasome signaling at multiple steps. Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance. |
| doi_str_mv | 10.1038/ni.2237 |
| format | Article |
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| ispartof | Nature immunology, 2012-04, Vol.13 (4), p.333-342 |
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| subjects | 631/250/254 631/250/256/2177 631/250/262 Animals Biomedical and Life Sciences Biomedicine Cellular proteins Cellular signal transduction Cytokines Humans IL-1β Immune response Immunity, Innate - immunology Immunology Infectious Diseases Inflammasomes Inflammasomes - immunology Inflammasomes - metabolism Inflammation Innate immunity Interleukin 1 Interleukin 18 Physiological aspects Pyroptosis review-article Signal Transduction - immunology |
| title | Regulation of inflammasome signaling |
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