Chemotherapy disrupts learning, neurogenesis and theta activity in the adult brain

Chemotherapy, especially if prolonged, disrupts attention, working memory and speed of processing in humans. Most cancer drugs that cross the blood–brain barrier also decrease adult neurogenesis. Because new neurons are generated in the hippocampus, this decrease may contribute to the deficits in wo...

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Veröffentlicht in:	The European journal of neuroscience 2012-12, Vol.36 (11), p.3521-3530
Hauptverfasser:	Nokia, Miriam S., Anderson, Megan L., Shors, Tracey J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Antineoplastic Agents, Alkylating - toxicity Association Learning - drug effects Associative learning Attention Blood-brain barrier Brain Cancer cancer therapy Chemotherapy Classical conditioning Conditioning, Eyelid Dacarbazine - analogs & derivatives Dacarbazine - toxicity Hippocampus Hippocampus - drug effects Hippocampus - physiopathology Male Memory Memory, Long-Term - drug effects Memory, Short-Term - drug effects Nervous system Neurogenesis Neurogenesis - drug effects rat Rats Rats, Sprague-Dawley Short term memory temozolomide theta Theta Rhythm - drug effects
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