Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules
Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the la...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2012-10, Vol.27 (10), p.1847-1854 |
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| creator | Lu, Christopher Y. Winterberg, Pamela D. Chen, Jianlin Hartono, John R. |
| description | Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia–reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal–spatial roles and potential therapeutics targeting this particular receptor–ligand interaction are also explored. |
| doi_str_mv | 10.1007/s00467-011-2029-0 |
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Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia–reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal–spatial roles and potential therapeutics targeting this particular receptor–ligand interaction are also explored.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-011-2029-0</identifier><identifier>PMID: 22033798</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acute Kidney Injury - immunology ; Acute Kidney Injury - pathology ; Animals ; Chromosomal proteins ; Conspiracy ; Endothelial Cells - immunology ; Endothelial Cells - pathology ; HMGB1 Protein - metabolism ; Humans ; Immune system ; Immunity, Innate ; Infections ; Inflammation ; Inflammation - immunology ; Ischemia ; Kidney diseases ; Kidney transplants ; Kidney Tubules - immunology ; Kidney Tubules - pathology ; Leukocytes ; Leukocytes - immunology ; Leukocytes - pathology ; Ligands ; Medicine ; Medicine & Public Health ; Mortality ; Mutation ; Nephrology ; Pathogenesis ; Pathogens ; Pediatrics ; Review ; Signal Transduction ; Toll-Like Receptor 4 - metabolism ; Urology</subject><ispartof>Pediatric nephrology (Berlin, West), 2012-10, Vol.27 (10), p.1847-1854</ispartof><rights>IPNA 2011</rights><rights>COPYRIGHT 2012 Springer</rights><rights>IPNA 2012</rights><rights>IPNA 2011 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-eafb3c0c9478c6a8b348fcbdf14e1093046dfd15b4a5b8907312765a09f70aef3</citedby><cites>FETCH-LOGICAL-c606t-eafb3c0c9478c6a8b348fcbdf14e1093046dfd15b4a5b8907312765a09f70aef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-011-2029-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-011-2029-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22033798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Christopher Y.</creatorcontrib><creatorcontrib>Winterberg, Pamela D.</creatorcontrib><creatorcontrib>Chen, Jianlin</creatorcontrib><creatorcontrib>Hartono, John R.</creatorcontrib><title>Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia–reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal–spatial roles and potential therapeutics targeting this particular receptor–ligand interaction are also explored.</description><subject>Acute Kidney Injury - immunology</subject><subject>Acute Kidney Injury - pathology</subject><subject>Animals</subject><subject>Chromosomal proteins</subject><subject>Conspiracy</subject><subject>Endothelial Cells - immunology</subject><subject>Endothelial Cells - pathology</subject><subject>HMGB1 Protein - metabolism</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Innate</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Ischemia</subject><subject>Kidney diseases</subject><subject>Kidney transplants</subject><subject>Kidney Tubules - immunology</subject><subject>Kidney Tubules - pathology</subject><subject>Leukocytes</subject><subject>Leukocytes - immunology</subject><subject>Leukocytes - pathology</subject><subject>Ligands</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Nephrology</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Pediatrics</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Toll-Like Receptor 4 - metabolism</subject><subject>Urology</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kl2LEzEUhgdR3Lr6A7yRgCBe7Kwnk_lIvBDK4hcseKOwdzGTOWnTpklNZoT-e1O6Lq1UchHIed43OSdvUbykcE0BuncJoG67EigtK6hECY-KGa1ZVVLB7x4XMxCMllDTu4viWUorAOANb58WF1UFjHWCz4qfcz2NSNZ28Lgj1q-muHtPFNHBp62NSu9IMGQMzpXOrpFE1LgdQyQ1CZ6gH8K4RGfVFXE4rYPejZiuiPIDGad-cpieF0-Mcglf3O-XxY9PH7_ffClvv33-ejO_LXUL7ViiMj3ToEXdcd0q3rOaG90PhtZIcx-50cEMtOlr1fRcQMdo1bWNAmE6UGjYZfHh4Lud-g0OGv0YlZPbaDcq7mRQVp5WvF3KRfgtWVMxykU2eHtvEMOvCdMoNzZpdE55DFOSFFjd0I4zltHX_6CrMEWf25O0FhWFqhVH1EI5lNabkO_Ve1M5Zw00XSN4nanyDLVAj_mRwaOx-fiEvz7D5zXgxuqzgjdHgiUqNy5TcNNo8xefgvQA6hhSimgehkdB7vMmD3mTOW9ynzcJWfPqeOoPir8By0B1AFIu-QXGo1H91_UPf4jecQ</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Lu, Christopher Y.</creator><creator>Winterberg, Pamela D.</creator><creator>Chen, Jianlin</creator><creator>Hartono, John R.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121001</creationdate><title>Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules</title><author>Lu, Christopher Y. ; Winterberg, Pamela D. ; Chen, Jianlin ; Hartono, John R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-eafb3c0c9478c6a8b348fcbdf14e1093046dfd15b4a5b8907312765a09f70aef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Kidney Injury - immunology</topic><topic>Acute Kidney Injury - pathology</topic><topic>Animals</topic><topic>Chromosomal proteins</topic><topic>Conspiracy</topic><topic>Endothelial Cells - immunology</topic><topic>Endothelial Cells - pathology</topic><topic>HMGB1 Protein - metabolism</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity, Innate</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Inflammation - immunology</topic><topic>Ischemia</topic><topic>Kidney diseases</topic><topic>Kidney transplants</topic><topic>Kidney Tubules - immunology</topic><topic>Kidney Tubules - pathology</topic><topic>Leukocytes</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - pathology</topic><topic>Ligands</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Mutation</topic><topic>Nephrology</topic><topic>Pathogenesis</topic><topic>Pathogens</topic><topic>Pediatrics</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>Toll-Like Receptor 4 - metabolism</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Christopher Y.</creatorcontrib><creatorcontrib>Winterberg, Pamela D.</creatorcontrib><creatorcontrib>Chen, Jianlin</creatorcontrib><creatorcontrib>Hartono, John R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Christopher Y.</au><au>Winterberg, Pamela D.</au><au>Chen, Jianlin</au><au>Hartono, John R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>27</volume><issue>10</issue><spage>1847</spage><epage>1854</epage><pages>1847-1854</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia–reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal–spatial roles and potential therapeutics targeting this particular receptor–ligand interaction are also explored.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22033798</pmid><doi>10.1007/s00467-011-2029-0</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Kidney Injury - immunology Acute Kidney Injury - pathology Animals Chromosomal proteins Conspiracy Endothelial Cells - immunology Endothelial Cells - pathology HMGB1 Protein - metabolism Humans Immune system Immunity, Innate Infections Inflammation Inflammation - immunology Ischemia Kidney diseases Kidney transplants Kidney Tubules - immunology Kidney Tubules - pathology Leukocytes Leukocytes - immunology Leukocytes - pathology Ligands Medicine Medicine & Public Health Mortality Mutation Nephrology Pathogenesis Pathogens Pediatrics Review Signal Transduction Toll-Like Receptor 4 - metabolism Urology |
| title | Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules |
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