The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice

Genetically modified mice mimicking ODDD (oculodentodigital dysplasia), a disease characterized by reduced Cx43 (connexin 43)-mediated gap junctional intercellular communication, represent an in vivo model to assess the role of Cx43 in mammary gland development and function. We previously reported t...

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Veröffentlicht in:	Biochemical journal 2013-01, Vol.449 (2), p.401-413
Hauptverfasser:	Stewart, Michael K G, Gong, Xiang-Qun, Barr, Kevin J, Bai, Donglin, Fishman, Glenn I, Laird, Dale W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line, Tumor Cells, Cultured Connexin 43 - genetics Connexin 43 - metabolism Craniofacial Abnormalities - genetics Craniofacial Abnormalities - metabolism Craniofacial Abnormalities - pathology Disease Models, Animal Epithelial Cells - metabolism Eye Abnormalities - genetics Eye Abnormalities - metabolism Eye Abnormalities - pathology Female Foot Deformities, Congenital - genetics Foot Deformities, Congenital - metabolism Foot Deformities, Congenital - pathology Gap Junctions - metabolism Gap Junctions - pathology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Lactation - drug effects Lactation - genetics Male Mammary Glands, Animal - abnormalities Mammary Glands, Animal - metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Microscopy, Fluorescence Oxytocin - pharmacology Point Mutation Pregnancy Severity of Illness Index Syndactyly - genetics Syndactyly - metabolism Syndactyly - pathology Tooth Abnormalities - genetics Tooth Abnormalities - metabolism Tooth Abnormalities - pathology
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