Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation

Escherichia coli DksA is a transcription factor that binds to RNA polymerase (RNAP) without binding to DNA, destabilizing RNAP-promoter interactions, sensitizing RNAP to the global regulator ppGpp, and regulating transcription of several hundred target genes, including those encoding rRNA. Previousl...

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Veröffentlicht in:	Genes & development 2012-12, Vol.26 (23), p.2634-2646
Hauptverfasser:	Lennon, Christopher W, Ross, Wilma, Martin-Tumasz, Stephen, Toulokhonov, Innokenti, Vrentas, Catherine E, Rutherford, Steven T, Lee, Jeong-Hyun, Butcher, Samuel E, Gourse, Richard L
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Regulation, Bacterial Models, Molecular Phenylalanine - analogs & derivatives Phenylalanine - metabolism Promoter Regions, Genetic - genetics Protein Binding Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - metabolism Research Paper
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