The role of PR-Set7 in replication licensing depends on Suv4-20h

PR-Set7 is the sole monomethyltransferase responsible for H4K20 monomethylation (H4K20me1) that is the substrate for further methylation by Suv4-20h1/h2. PR-Set7 is required for proper cell cycle progression and is subject to degradation by the CRL4(Cdt2) ubiquitin ligase complex as a function of th...

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Veröffentlicht in:	Genes & development 2012-12, Vol.26 (23), p.2580-2589
Hauptverfasser:	Beck, David B, Burton, Adam, Oda, Hisanobu, Ziegler-Birling, Céline, Torres-Padilla, Maria-Elena, Reinberg, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - genetics Cell Cycle - physiology Cell Differentiation Cell Line, Tumor Cell Proliferation DNA Damage DNA Replication - genetics DNA Replication - physiology Embryo, Mammalian Fibroblasts - cytology Genetics HeLa Cells Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Life Sciences Mice Origin Recognition Complex - metabolism Protein Binding Research Paper Ubiquitin-Protein Ligases - metabolism
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